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Microwave-assisted ...
Microwave-assisted transition-metal-catalyzed synthesis of N-shifted and ring-expanded buflavine analogues
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- Appukkuttan, Prasad (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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Dehaen, Wim (author)
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Van der Eycken, Erik (author)
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(creator_code:org_t)
- Wiley, 2007
- 2007
- English.
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In: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 13:22, s. 6452-6460
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Two novel and efficient strategies for the synthesis of hitherto unknown N-shifted and ring-expanded buflavine analogues are presented. Construction of the medium-sized ring system of the title molecules, a difficult task due to the high activation energy needed for the ring-closure with the additional rigidity imposed by the biaryl skeleton, was achieved by using Suzuki-Miyaura biaryl coupling and a ring-closing metathesis reaction as the key steps. The combination of a second-generation Grubbs catalyst and microwave irradiation proved to be highly useful in generating the otherwise difficult to obtain medium-sized ring system of the buflavine analogues.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- buflavine
- cross-coupling
- medium-sized rings
- metathesis
- microwave irradiation
- PHARMACY
- FARMACI
Publication and Content Type
- vet (subject category)
- art (subject category)
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