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Distinct Neural Ste...
Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC
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- Swartling, Fredrik J. (author)
- Uppsala universitet,Cancer och vaskulärbiologi
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- Savov, Vasil (author)
- Uppsala universitet,Cancer och vaskulärbiologi
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Persson, Anders I. (author)
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Chen, Justin (author)
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Hackett, Christopher S. (author)
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Northcott, Paul A. (author)
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Grimmer, Matthew R. (author)
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Lau, Jasmine (author)
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Chesler, Louis (author)
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Perry, Arie (author)
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Phillips, Joanna J. (author)
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Taylor, Michael D. (author)
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Weiss, William A. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 21:5, s. 601-613
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally stabilized murine N-myc(T58A) into neural stem cells (NSCs) from perinatal murine cerebellum, brain stem, and forebrain. Transplantation of N-myc(WT) NSCs was insufficient for tumor formation. N-myc(T58A) cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma. Expression analyses distinguished tumors generated from these different regions, with tumors from embryonic versus postnatal cerebellar NSCs demonstrating Sonic Hedgehog (SHH) dependence and SHH independence, respectively. These differences were regulated in part by the transcription factor SOX9, activated in the SHH subclass of human medulloblastoma. Our results demonstrate context-dependent transformation of NSCs in response to a common oncogenic signal.
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- art (subject category)
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- By the author/editor
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Swartling, Fredr ...
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Savov, Vasil
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Persson, Anders ...
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Chen, Justin
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Hackett, Christo ...
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Northcott, Paul ...
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show more...
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Grimmer, Matthew ...
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Lau, Jasmine
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Chesler, Louis
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Perry, Arie
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Phillips, Joanna ...
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Taylor, Michael ...
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Weiss, William A ...
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show less...
- Articles in the publication
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Cancer Cell
- By the university
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Uppsala University