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Stereotyped B-cell ...
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia : a molecular classification with implications for targeted therapies
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Agathangelidis, Andreas (author)
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Darzentas, Nikos (author)
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Hadzidimitriou, Anastasia (author)
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Brochet, Xavier (author)
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Murray, Fiona (author)
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Yan, Xiao-Jie (author)
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Davis, Zadie (author)
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van Gastel-Mol, Ellen J. (author)
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Tresoldi, Cristina (author)
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Chu, Charles C. (author)
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- Cahill, Nicola (author)
- Uppsala universitet,Hematologi och immunologi,Rosenquist Brandell
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Giudicelli, Veronique (author)
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Tichy, Boris (author)
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Pedersen, Lone Bredo (author)
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Foroni, Letizia (author)
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Bonello, Lisa (author)
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Janus, Agnieszka (author)
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Smedby, Karin (author)
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Anagnostopoulos, Achilles (author)
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Merle-Beral, Helene (author)
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Laoutaris, Nikolaos (author)
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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di Celle, Paola Francia (author)
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Pospisilova, Sarka (author)
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Jurlander, Jesper (author)
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Geisler, Christian (author)
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Tsaftaris, Athanasios (author)
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Lefranc, Marie-Paule (author)
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Langerak, Anton W. (author)
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Oscier, David Graham (author)
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Chiorazzi, Nicholas (author)
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Belessi, Chrysoula (author)
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Davi, Frederic (author)
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- Rosenquist Brandell, Richard (author)
- Uppsala universitet,Hematologi och immunologi,Rosenquist Brandell
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Ghia, Paolo (author)
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Stamatopoulos, Kostas (author)
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(creator_code:org_t)
- American Society of Hematology, 2012
- 2012
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 119:19, s. 4467-4475
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However, several issues need revisiting, including the criteria for identification of BCR stereotypy and its actual frequency as well as the identification of "CLL-biased" features in BCR Ig stereotypes. To this end, we examined 7596 Ig VH (IGHV-IGHD-IGHJ) sequences from 7424 CLL patients, 3 times the size of the largest published series, with an updated version of our purpose-built clustering algorithm. We document that CLL may be subdivided into 2 distinct categories: one with stereotyped and the other with nonstereotyped BCRs, at an approximate ratio of 1: 2, and provide evidence suggesting a different ontogeny for these 2 categories. We also show that subset-defining sequence patterns in CLL differ from those underlying BCR stereotypy in other B-cell malignancies. Notably, 19 major subsets contained from 20 to 213 sequences each, collectively accounting for 943 sequences or one-eighth of the cohort. Hence, this compartmentalized examination of VH sequences may pave the way toward a molecular classification of CLL with implications for targeted therapeutic interventions, applicable to a significant number of patients assigned to the same subset.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Blood
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To the university's database
- By the author/editor
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Agathangelidis, ...
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Darzentas, Nikos
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Hadzidimitriou, ...
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Brochet, Xavier
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Murray, Fiona
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Yan, Xiao-Jie
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show more...
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Davis, Zadie
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van Gastel-Mol, ...
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Tresoldi, Cristi ...
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Chu, Charles C.
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Cahill, Nicola
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Giudicelli, Vero ...
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Tichy, Boris
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Pedersen, Lone B ...
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Foroni, Letizia
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Bonello, Lisa
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Janus, Agnieszka
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Smedby, Karin
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Anagnostopoulos, ...
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Merle-Beral, Hel ...
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Laoutaris, Nikol ...
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Juliusson, Gunna ...
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di Celle, Paola ...
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Pospisilova, Sar ...
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Jurlander, Jespe ...
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Geisler, Christi ...
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Tsaftaris, Athan ...
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Lefranc, Marie-P ...
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Langerak, Anton ...
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Oscier, David Gr ...
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Chiorazzi, Nicho ...
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Belessi, Chrysou ...
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Davi, Frederic
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Rosenquist Brand ...
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Ghia, Paolo
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Stamatopoulos, K ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet