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The Crest Phenotype...
The Crest Phenotype in Chicken Is Associated with Ectopic Expression of HOXC8 in Cranial Skin
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Wang, Yanqiang (author)
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Gao, Yu (author)
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- Imsland, Freyja (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Gu, Xiaorong (author)
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Feng, Chungang (author)
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Liu, Ranran (author)
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Song, Chi (author)
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Tixier-Boichard, Michele (author)
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Gourichon, David (author)
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Li, Qingyuan (author)
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Chen, Kuanwei (author)
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Li, Huifang (author)
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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Hu, Xiaoxiang (author)
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Li, Ning (author)
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(creator_code:org_t)
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- 2012-04-13
- 2012
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:4, s. e34012-
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Abstract
Subject headings
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- The Crest phenotype is characterised by a tuft of elongated feathers atop the head. A similar phenotype is also seen in several wild bird species. Crest shows an autosomal incompletely dominant mode of inheritance and is associated with cerebral hernia. Here we show, using linkage analysis and genome-wide association, that Crest is located on the E22C19W28 linkage group and that it shows complete association to the HOXC-cluster on this chromosome. Expression analysis of tissues from Crested and non-crested chickens, representing 26 different breeds, revealed that HOXC8, but not HOXC12 or HOXC13, showed ectopic expression in cranial skin during embryonic development. We propose that Crest is caused by a cis-acting regulatory mutation underlying the ectopic expression of HOXC8. However, the identification of the causative mutation(s) has to await until a method becomes available for assembling this chromosomal region. Crest is unfortunately located in a genomic region that has so far defied all attempts to establish a contiguous sequence.
Subject headings
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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PLOS ONE
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To the university's database
- By the author/editor
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Wang, Yanqiang
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Gao, Yu
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Imsland, Freyja
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Gu, Xiaorong
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Feng, Chungang
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Liu, Ranran
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show more...
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Song, Chi
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Tixier-Boichard, ...
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Gourichon, David
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Li, Qingyuan
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Chen, Kuanwei
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Li, Huifang
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Andersson, Leif
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Hu, Xiaoxiang
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Li, Ning
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Genetics and Bre ...
- Articles in the publication
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PLOS ONE
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences