Heterozygosity-fitness correlations in zebra finches: microsatellite markers can be better than their reputation

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-177854" > Heterozygosity-fitn...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Forstmeier, Wolfgang (author)

Heterozygosity-fitness correlations in zebra finches : microsatellite markers can be better than their reputation

Article/chapterEnglish2012

Publisher, publication year, extent ...

2012
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-177854
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177854URI
https://doi.org/10.1111/j.1365-294X.2012.05593.xDOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Numerous studies have reported associations between heterozygosity in microsatellite markers and fitness-related traits (heterozygosityfitness correlations, HFCs). However, it has often been questioned whether HFCs reflect general inbreeding depression, because a small panel of microsatellite markers does not reflect very well an individuals inbreeding coefficient (F) as calculated from a pedigree. Here, we challenge this prevailing view. Because of chance events during Mendelian segregation, an individuals realized proportion of the genome that is identical by descent (IBD) may substantially deviate from the pedigree-based expectation (i.e. F). This Mendelian noise may result in a weak correlation between F and multi-locus heterozygosity, but this does not imply that multi-locus heterozygosity is a bad estimator of realized IBD. We examined correlations between 11 fitness-related traits measured in up to 1192 captive zebra finches and three measures of inbreeding: (i) heterozygosity across 11 microsatellite markers, (ii) heterozygosity across 1359 single-nucleotide polymorphism (SNP) markers and (iii) F, based on a 5th-generation pedigree. All 11 phenotypic traits showed positive relationships with measures of heterozygosity, especially traits that are most closely related to fitness. Remarkably, the small panel of microsatellite markers produced equally strong HFCs as the large panel of SNP markers. Both marker-based approaches produced stronger correlations with phenotypes than the pedigree-based F, and this did not seem to result from the shortness of our pedigree. We argue that a small panel of microsatellites with high allelic richness may better reflect an individuals realized IBD than previously appreciated, especially in species like the zebra finch, where much of the genome is inherited in large blocks that rarely experience cross-over during meiosis.

Subject headings and genre

NATURVETENSKAP Biologi Evolutionsbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Evolutionary Biology hsv//eng
identity by descent
inbreeding coefficient
inbreeding depression
pedigree
single-nucleotide polymorphism markers

Added entries (persons, corporate bodies, meetings, titles ...)

Schielzeth, HolgerUppsala universitet,Evolutionsbiologi(Swepub:uu)holsc837 (author)
Mueller, Jakob C. (author)
Ellegren, HansUppsala universitet,Evolutionsbiologi(Swepub:uu)hanselle (author)
Kempenaers, Bart (author)
Uppsala universitetEvolutionsbiologi (creator_code:org_t)

Related titles

In:Molecular Ecology21:13, s. 3237-32490962-10831365-294X

Internet link

Find in a library

Molecular Ecology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Forstmeier, Wolf ...; Schielzeth, Holg ...; Mueller, Jakob C ...; Ellegren, Hans; Kempenaers, Bart

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Evolutionary Bio ...

Articles in the publication: Molecular Ecolog ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se