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MYC+ diffuse large ...
MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation
- Article/chapterEnglish2012
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American Society of Hematology,2012
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LIBRIS-ID:oai:DiVA.org:uu-178875
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178875URI
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https://doi.org/10.1182/blood-2012-01-406033DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Approximately 5-10% of diffuse large B-cell lymphomas (DLBCL) harbor a 8q24/MYC rearrangement (MYC+). We determined the prognostic significance of MYC rearrangement in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed by highdose therapy and autologous stem cell transplantation. Twenty-eight (17%) of the 161 patients analyzed presented a MYC+ rearrangement, targeted as either simple hit (25%) or complex hits (n = 75%) including MYC/BCL2, MYC/BCL6, and MYC/BCL2/BCL6. Results were statistically highly concordant in matched primary and relapsed biopsies (n = 45). Compared to the MYC+ DLBCL patients, the MYC+ DLBCL patients presented with a more elevated lactico-deshydrogenase level (P = .0006) and a more advanced age adjusted international prognostic index (P = .0039). The 4-year PFS and OS were significantly lower in the MYC+ DLBCL patients than those in the MYC- DLBCL patients, with rates of 18% vs 42% (P = .0322), and of 29% vs 62% (P = .0113), respectively. Type of treatment, R-DHAP or R-ICE, had no impact on survivals, with 4-year PFS rates of 17% vs 19% and 4-year OS rates of 26% vs 31%. In conclusion, MYC rearrangement is an early event in DLBCL. MYC+ DLBCL patients have a significant inferior prognosis than MYC- DLBCL patients. Their outcome was not influenced by the proposed salvage therapy.
Added entries (persons, corporate bodies, meetings, titles ...)
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Briere, Josette
(author)
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Mounier, Nicolas
(author)
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Voelker, Hans-Ullrich
(author)
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Rosenwald, Andreas
(author)
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Sundström, ChristerUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)chrisund
(author)
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Cogliatti, Sergio
(author)
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Hirchaud, Edouard
(author)
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Ysebaert, Loic
(author)
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Bron, Dominique
(author)
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Soulier, Jean
(author)
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Gaulard, Philippe
(author)
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Houlgatte, Remi
(author)
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Gisselbrecht, Christian
(author)
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Thieblemont, Catherine
(author)
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Uppsala universitetMolekylär och morfologisk patologi
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology119:20, s. 4619-46240006-49711528-0020
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Cuccuini, Wendy
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Briere, Josette
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Cogliatti, Sergi ...
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Bron, Dominique
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