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Insulin receptor su...
Insulin receptor substrate-2 gene variants in subjects with metabolic syndrome : Association with plasma monounsaturated and n-3 polyunsaturated fatty acid levels and insulin resistance
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Perez-Martinez, Pablo (author)
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Delgado-Lista, Javier (author)
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Garcia-Rios, Antonio (author)
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Tierney, Audrey C. (author)
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Gulseth, Hanne L. (author)
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Williams, Christine M. (author)
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- Karlström, Brita (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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Kiec-Wilk, Beata (author)
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Blaak, Ellen E. (author)
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Helal, Olfa (author)
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Saris, Wim H. M. (author)
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Defoort, Catherine (author)
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Drevon, Christian A. (author)
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Lovegrove, Julie A. (author)
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Dembinska-Kiec, Aldona (author)
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Riserus, Ulf (author)
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Roche, Helen M. (author)
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Lopez-Miranda, Jose (author)
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(creator_code:org_t)
- 2012-04-17
- 2012
- English.
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In: Molecular Nutrition & Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 56:2, s. 309-315
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Scope: Several insulin receptor substrate-2 (IRS-2) polymorphisms have been studied in relation to insulin resistance and type 2 diabetes. To examine whether the genetic variability at the IRS-2 gene locus was associated with the degree of insulin resistance and plasma fatty acid levels in metabolic syndrome (MetS) subjects.Methods and results: Insulin sensitivity, insulin secretion, glucose effectiveness, plasma fatty acid composition and three IRS-2 tag-single nucleotide polymorphisms (SNPs) were determined in 452 MetS subjects. Among subjects with the lowest level of monounsaturated (MUFA) (below the median), the rs2289046 A/A genotype was associated with lower glucose effectiveness (p < 0.038), higher fasting insulin concentrations (p < 0.028) and higher HOMA IR (p < 0.038) as compared to subjects carrying the minor G-allele (A/G and G/G). In contrast, among subjects with the highest level of MUFA (above the median), the A/A genotype was associated with lower fasting insulin concentrations and HOMA-IR, whereas individuals carrying the G allele and with the highest level of omega-3 polyunsaturated fatty acids (above the median) showed lower fasting insulin (p < 0.01) and HOMA-IR (p < 0.02) as compared with A/A subjects.Conclusion: The rs2289046 polymorphism at the IRS2 gene locus may influence insulin sensitivity by interacting with certain plasma fatty acids in MetS subjects.
Keyword
- Fatty acids
- Metabolic syndrome
- Nutrigenomics
- n-3 PUFA
- Polymorphism
Publication and Content Type
- ref (subject category)
- art (subject category)
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Perez-Martinez, ...
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Delgado-Lista, J ...
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Garcia-Rios, Ant ...
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Tierney, Audrey ...
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Gulseth, Hanne L ...
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Williams, Christ ...
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show more...
-
Karlström, Brita
-
Kiec-Wilk, Beata
-
Blaak, Ellen E.
-
Helal, Olfa
-
Saris, Wim H. M.
-
Defoort, Catheri ...
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Drevon, Christia ...
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Lovegrove, Julie ...
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Dembinska-Kiec, ...
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Riserus, Ulf
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Roche, Helen M.
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Lopez-Miranda, J ...
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show less...
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Molecular Nutrit ...
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Uppsala University