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Abstract
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- Mantle cell lymphoma (MCL) is a heterogenic non-Hodgkin lymphoma entity, with a median survival of about 5 years. In 2008 we reported the early based on the median observation time of 4 years results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy and autologous stem cell transplantation (ASCT), with more than 60% event-free survival at 5 years, and no subsequent relapses reported. Here we present an update after a median observation time of 6.5 years. The overall results are still excellent, with median overall survival and response duration longer than 10 years, and a median event-free survival of 7.4 years. However, six patients have now progressed later than 5 years after end of treatment. The international MCL Prognostic Index (MIPI) and Ki-67-expression were the only independent prognostic factors. Subdivided by the MIPI-Biological Index (MIPI + Ki-67, MIPI-B), more than 70% of patients with low-intermediate MIPI-B were alive at 10 years, but only 23% of the patients with high MIPI-B. These results, although highly encouraging regarding the majority of the patients, underline the need of a risk-adapted treatment strategy for MCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- mantle cell lymphoma
- autologous stem cell transplant
- high-dose AraC
- rituximab
- pre-emptive therapy
- mantle cell lymphoma
- autologous stem cell transplant
- high-dose AraC
- rituximab
- pre-emptive therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
To the university's database
- By the author/editor
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Geisler, Christi ...
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Kolstad, Arne
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Laurell, Anna
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Jerkeman, Mats
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Raty, Riikka
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Andersen, Niels ...
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show more...
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Pedersen, Lone B ...
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Eriksson, Mikael
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Nordstrom, Marie
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Kimby, Eva
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Bentzen, Hans
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Kuittinen, Outi
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Lauritzsen, Gret ...
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Nilsson-Ehle, He ...
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Ralfkiaer, Elisa ...
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Ehinger, Mats
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Sundström, Chris ...
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Delabie, Jan
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Karjalainen-Lind ...
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Brown, Peter
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Elonen, Erkki
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet