Search: onr:"swepub:oai:DiVA.org:uu-179954" >
11C Molecular Imagi...
11C Molecular Imaging in Focal Epilepsy
-
- Danfors, Torsten, 1964- (author)
- Uppsala universitet,Neurologi,Enheten för nuklearmedicin och PET
-
- Kumlien, Eva, Docent (thesis advisor)
- Uppsala universitet,Neurologi
-
- Sörensen, Jens, Docent (thesis advisor)
- Uppsala universitet,Enheten för nuklearmedicin och PET
-
show more...
-
- Ronne-Engström, Elisabeth, Professor (thesis advisor)
- Uppsala universitet,Neurokirurgi
-
- Rinne, Juha, Professor (opponent)
- Turku PET Centre,. University of Turku and Turku. University Hospital,. Kiinamyllynkatu 4-8, 20520. Turku, Finland
-
show less...
-
(creator_code:org_t)
- ISBN 9789155484750
- Uppsala : Acta Universitatis Upsaliensis, 2012
- English 58 s.
-
Series: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 814
- Related links:
-
https://uu.diva-port... (primary) (Raw object)
-
show more...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Epilepsy is a common neurological disease affecting 6 million people in Europe. Early prevention and accurate diagnosis and treatment are of importance to obtain seizure freedom. In this thesis new applications of carbon-11-labelled tracers in PET and autoradiographic studies were explored in focal epilepsy.Patients with low-grade gliomas often experience epileptic seizures. A retrospective PET-study assessing seizure activity, metabolic rate measured with 11C-methionine and other known prognostic factors was performed in patients with glioma. No correlation was found between seizure activity and uptake of methionine. The presence and termination of early seizures was a favourable prognostic factor.Activation of the neurokinin-1 (NK1) receptor by substance P (SP) induces epileptic activity. PET with the NK1 receptor antagonist GR205171 was performed in patients with temporal lobe epilepsy (TLE) and healthy controls. In TLE patients an increased NK1 receptor availability was found in both hemispheres, most pronounced in anterior cingulate gyrus ipsilateral to seizure onset. A positive correlation between NK1 receptors and seizure frequency was observed in ipsilateral medial structures consistent with an intrinsic network using the NK1-SP receptor system for transmission of seizure activity.The uptake of 18F-fluoro-deoxy-glucose (FDG) is related to cerebral blood flow (CBF). Previously, methods to estimate blood flow from dynamic PET data have been described. A retrospective study was conducted in 15 patients undergoing epilepsy surgery investigation, including PET with 11C-FDG and 11C-Flumazenil (FMZ). The dynamic FMZ dataset and pharmacokinetic modeling with a multilinear reference tissue model were used to determine images of relative CBF. Agreement between data of FDG and CBF was analyzed showing a close association between interictal brain metabolism and relative CBF.Epilepsy often occurs after traumatic brain injuries. Changes in glia and inhibitory neuronal cells contribute to the chain of events leading to seizures. Autoradiography with 11C-PK11195, 11C-L-deprenyl and 11C-Flumazenil in an animal model of posttraumatic epilepsy studied the temporal and spatial distribution of microglia, astrocytes and GABAergic neurons. Results showed an instant increase in microglial activity that subsequently normalized, a late formation of astrogliosis and an instant and prolonged decease in GABA binding. The model can be used to visualize pathophysiological events during the epileptogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- positron emission tomography
- methionine
- NK1
- substance p
- flumazenil
- deprenyl
- pk11195
- phosphoimager
- autoradiography
- TBI
- traumatic brain injury
- iron chloride
- ferrous chloride
- Neurology
- Neurologi
- Radiology
- Radiologi
Publication and Content Type
- vet (subject category)
- dok (subject category)
Find in a library
To the university's database