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T cells engineered ...
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Hillerdal, VictoriaUppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
(author)
T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-09-10
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Proceedings of the National Academy of Sciences,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-181199
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181199URI
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https://doi.org/10.1073/pnas.1209042109DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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To produce genetically engineered T cells directed against prostate and breast cancer cells, we have cloned the T-cell receptor recognizing the HLA-A2–restricted T-cell recptor γ-chain alternate reading-frame protein (TARP)4–13 epitope. TARP is a protein exclusively expressed in normal prostate epithelium and in adenocarcinomas of the prostate and breast. Peripheral blood T cells transduced with a lentiviral vector encoding the TARP-TCR proliferated well when exposed to peptide-specific stimuli. These cells exerted peptide-specific IFN-γ production and cytotoxic activity. Importantly, HLA-A2+ prostate and breast cancer cells expressing TARP were also killed, demonstrating that the TARP4–13 epitope is a physiologically relevant target for T-cell therapy of prostate and breast cancer. In conclusion, we present the cloning of a T cell receptor (TCR) directed against a physiologically relevant HLA-A2 epitope of TARP. To our knowledge this report on engineering of T cells with a TCR directed against an antigen specifically expressed by prostate cells is unique.
Added entries (persons, corporate bodies, meetings, titles ...)
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Nilsson, BerithUppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)benil498
(author)
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Carlsson, BjörnUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
(author)
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Eriksson, FredrikUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)freer194
(author)
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Essnd, MagnusUppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)magnessa
(author)
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Uppsala universitetKlinisk immunologi
(creator_code:org_t)
Related titles
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In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences109:39, s. 15877-158810027-84241091-6490
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