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Measurements of Brownian relaxation of magnetic nanobeads using planar Hall effect bridge sensors
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- Østerberg, F. W. (author)
- Dept of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Kongens Lyngby, Danmark
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- Rizzi, G. (author)
- Dept of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Kongens Lyngby, Danmark
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- Zardán Gómez de la Torre, Teresa (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanoteknologi och funktionella material, Nanotechnology and Functional Materials
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- (creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
- In: Biosensors & bioelectronics. - : Elsevier BV. - 0956-5663 .- 1873-4235. ; 40:S1, s. 147-152
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We compare measurements of the Brownian relaxation response of magnetic nanobeads in suspension using planar Hall effect sensors of cross geometry and a newly proposed bridge geometry. We find that the bridge sensor yields six times as large signals as the cross sensor, which results in a more accurate determination of the hydrodynamic size of the magnetic nanobeads. Finally, the bridge sensor has successfully been used to measure the change in dynamic magnetic response when rolling circle amplified DNA molecules are bound to the magnetic nanobeads. The change is validated by measurements performed in a commercial AC susceptometer. The presented bridge sensor is, thus, a promising component in future lab-on-a-chip biosensors for detection of clinically relevant analytes, including bacterial genomic DNA and proteins.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Keyword
- TECHNOLOGY
- TEKNIKVETENSKAP
- Engineering Science with specialization in Solid State Physics
- Teknisk fysik med inriktning mot fasta tillståndets fysik
- Engineering Science with specialization in Nanotechnology and Functional Materials
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
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- ref (subject category)
- art (subject category)
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- Svedlindh, Peter
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- Hansen, M. F.
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