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Implementation of p...
Implementation of proteomic biomarkers : making it work
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-04-21
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Wiley,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-181838
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181838URI
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https://doi.org/10.1111/j.1365-2362.2012.02674.xDOI
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https://res.slu.se/id/publ/41725URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implementation. Some of the problems lie in suboptimal biomarker discovery and validation, especially lack of validated platforms with well-described performance characteristics to support biomarker qualification. These issues have been acknowledged and are being addressed, raising the hope that valid biomarkers may start accumulating in the foreseeable future. However, successful biomarker discovery and qualification alone does not suffice for successful implementation. Additional challenges include, among others, limited access to appropriate specimens and insufficient funding, the need to validate new biomarker utility in interventional trials, and large communication gaps between the parties involved in implementation. To address this problem, we propose an implementation roadmap. The implementation effort needs to involve a wide variety of stakeholders (clinicians, statisticians, health economists, and representatives of patient groups, health insurance, pharmaceutical companies, biobanks, and regulatory agencies). Knowledgeable panels with adequate representation of all these stakeholders may facilitate biomarker evaluation and guide implementation for the specific context of use. This approach may avoid unwarranted delays or failure to implement potentially useful biomarkers, and may expedite meaningful contributions of the biomarker community to healthcare.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ioannidis, John P. A.
(author)
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Argiles, Angel
(author)
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Attwood, Teresa K.
(author)
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Bongcam Rudloff, ErikSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics(Swepub:slu)50410
(author)
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Broenstrup, Mark
(author)
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Charonis, Aristidis
(author)
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Chrousos, George P.
(author)
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Delles, Christian
(author)
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Dominiczak, Anna
(author)
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Dylag, Tomasz
(author)
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Ehrich, Jochen
(author)
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Egido, Jesus
(author)
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Findeisen, Peter
(author)
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Jankowski, Joachim
(author)
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Johnson, Robert W.
(author)
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Julien, Bruce A.
(author)
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Lankisch, Tim
(author)
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Leung, Hing Y.
(author)
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Maahs, David
(author)
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Magni, Fulvio
(author)
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Manns, Michael P.
(author)
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Manolis, Efthymios
(author)
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Mayer, Gert
(author)
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Navis, Gerjan
(author)
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Novak, Jan
(author)
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Ortiz, Alberto
(author)
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Persson, Frederik
(author)
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Peter, Karlheinz
(author)
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Riese, Hans H.
(author)
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Rossing, Peter
(author)
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Sattar, Naveed
(author)
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Spasovski, Goce
(author)
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Thongboonkerd, Visith
(author)
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Vanholder, Raymond
(author)
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Schanstra, Joost P.
(author)
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Vlahou, Antonia
(author)
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Uppsala universitetInstitutionen för immunologi, genetik och patologi
(creator_code:org_t)
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Sveriges lantbruksuniversitet
Related titles
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In:European Journal of Clinical Investigation: Wiley42:9, s. 1027-10360014-29721365-2362
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Mischak, Harald
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Ioannidis, John ...
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Argiles, Angel
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Attwood, Teresa ...
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Bongcam Rudloff, ...
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Broenstrup, Mark
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Charonis, Aristi ...
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Chrousos, George ...
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Delles, Christia ...
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Dominiczak, Anna
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Dylag, Tomasz
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Ehrich, Jochen
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Egido, Jesus
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Findeisen, Peter
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Jankowski, Joach ...
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Johnson, Robert ...
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Julien, Bruce A.
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Lankisch, Tim
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Leung, Hing Y.
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Maahs, David
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Magni, Fulvio
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Manns, Michael P ...
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Manolis, Efthymi ...
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Mayer, Gert
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Navis, Gerjan
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Novak, Jan
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Ortiz, Alberto
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Persson, Frederi ...
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Peter, Karlheinz
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Riese, Hans H.
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Rossing, Peter
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Sattar, Naveed
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Spasovski, Goce
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Thongboonkerd, V ...
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Vanholder, Raymo ...
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Schanstra, Joost ...
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Vlahou, Antonia
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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European Journal ...
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences