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Lipid Profiles and ...
Lipid Profiles and Risk of Breast and Ovarian Cancer in the Swedish AMORIS Study
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Melvin, Jennifer C. (author)
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Seth, Divya (author)
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- Holmberg, Lars (author)
- Uppsala universitet,Endokrinkirurgi
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Garmo, Hans (author)
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- Hammar, Niklas (author)
- Karolinska Institutet
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- Jungner, Ingmar (author)
- Karolinska Institutet
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- Walldius, Goran (author)
- Karolinska Institutet
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- Lambe, Mats (author)
- Karolinska Institutet
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Wigertz, Annette (author)
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Van Hemelrijck, Mieke (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 21:8, s. 1381-1384
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Obesity is a risk factor for breast and ovarian cancer; the mechanisms of action are not completely understood. Perturbed lipid metabolism often accompanies obesity; we therefore ascertained the associations between lipid components and breast and ovarian cancer risk in a prospective cohort study.Methods: A total of 234,494 women with baseline measurements of triglycerides and total cholesterol and glucose were selected from the AMORIS database.A total of 27,394 had measurements of high-density lipoprotein, low-density lipoprotein, apolipoprotein (Apo) B, and A-I. Associations between quartiles and dichotomized values of lipid components and breast and ovarian cancer risk were analyzed using Cox proportional hazard models.Results: We identified 6,105 women diagnosed with breast cancer and 808 women diagnosed with ovarian cancer. A weak trend was observed between triglycerides and breast cancer (HR, 1.01, 95% Confidence Interval, 0.94-1.09; 0.93 (0.86-1.00) 0.91 (0.84-0.99), second, third, and fourth quartiles; P = 0.01). No other associations between lipid components and risk of breast cancer or ovarian cancer showed statistical significance.Conclusions: A weak protective association was found between levels of triglycerides and risk of breast cancer.Impact: An analysis including information on tumour characteristics of ovarian cancer and breast cancer may provide more insight in possible links between lipid metabolism and the risk of these cancers.
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- By the author/editor
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Melvin, Jennifer ...
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Seth, Divya
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Holmberg, Lars
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Garmo, Hans
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Hammar, Niklas
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Jungner, Ingmar
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show more...
-
Walldius, Goran
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Lambe, Mats
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Wigertz, Annette
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Van Hemelrijck, ...
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show less...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Uppsala University
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Karolinska Institutet