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The prognostic rele...
The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer
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- Lohr, Miriam (author)
- Department of Statistics, Technical University Dortmund, Germany
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- Edlund, Karolina (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Botling, Johan (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Hammad, Seddik (author)
- Leibniz Research Centre for Working Environment and Human Factors (IfADo) at Dortmund TU, Dortmund, Germany
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- Hellwig, Birte (author)
- Department of Statistics, Technical University Dortmund, Germany
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- Othman, Amnah (author)
- Leibniz Research Centre for Working Environment and Human Factors (IfADo) at Dortmund TU, Dortmund, Germany
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Berglund, Anders (author)
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- Lambe, Mats (author)
- Karolinska Institutet
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- Holmberg, Lars (author)
- Uppsala universitet,Endokrinkirurgi
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- Ekman, Simon (author)
- Uppsala universitet,Enheten för onkologi
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- Bergqvist, Michael (author)
- Uppsala universitet,Enheten för onkologi
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- Pontén, Fredrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Cadenas, Cristina (author)
- Leibniz Research Centre for Working Environment and Human Factors (IfADo) at Dortmund TU, Dortmund, Germany
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- Marchan, Rosemarie (author)
- Leibniz Research Centre for Working Environment and Human Factors (IfADo) at Dortmund TU, Dortmund, Germany
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- Hengstler, Jan G. (author)
- Leibniz Research Centre for Working Environment and Human Factors (IfADo) at Dortmund TU, Dortmund, Germany
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- Rahnenfuhrer, Jörg (author)
- Department of Statistics, Technical University Dortmund, Germany
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- Micke, Patrick (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Cancer Letters. - : Elsevier BV. - 0304-3835 .- 1872-7980. ; 333:2, s. 222-228
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma–infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lohr, Miriam
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Edlund, Karolina
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Botling, Johan
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Hammad, Seddik
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Hellwig, Birte
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Othman, Amnah
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show more...
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Berglund, Anders
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Lambe, Mats
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Holmberg, Lars
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Ekman, Simon
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Bergqvist, Micha ...
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Pontén, Fredrik
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Cadenas, Cristin ...
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Marchan, Rosemar ...
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Hengstler, Jan G ...
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Rahnenfuhrer, Jö ...
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Micke, Patrick
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Letters
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet