Search: onr:"swepub:oai:DiVA.org:uu-182007" > Relations of circul...
Fältnamn | Indikatorer | Metadata |
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000 | 04871naa a2200529 4500 | |
001 | oai:DiVA.org:uu-182007 | |
003 | SwePub | |
008 | 121002s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:125125064 | |
009 | oai:DiVA.org:du-10573 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1820072 URI |
024 | 7 | a https://doi.org/10.1093/eurjhf/hfs0912 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1251250642 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-105732 URI |
040 | a (SwePub)uud (SwePub)kid (SwePub)du | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fall, Tove,d 1979-u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Sweden4 aut0 (Swepub:uu)tovfa878 |
245 | 1 0 | a Relations of circulating vitamin D concentrations with left ventricular geometry and function |
264 | c 2014-02-27 | |
264 | 1 | b Wiley,c 2012 |
338 | a print2 rdacarrier | |
520 | a Vitamin D deficiency has been associated with risk of overt cardiovascular disease (CVD), but associations with subclinical disease are not well characterized. Hence, we examined associations of circulating vitamin D concentrations and left ventricular (LV) geometry and function by echocardiography at baseline and after 5 years in a community-based study. In the PIVUS study, we measured serum 25-dihydroxyvitamin-D (25-OH D) at age 70 and performed echocardiography including LV mass, wall thickness, end-diastolic diameter, end-systolic diameter (LVESD), left atrial diameter, fractional shortening, ejection fraction, isovolumic relaxation time, and E/A ratio at both age 70 and 75. We included 870 participants (52 women) without prior myocardial infarctions, heart failure, or prevalent valvular disease. After adjusting for potential confounders, 25-OH D at baseline was found to be significantly associated with LVESD, fractional shortening, and ejection fraction (, 0.42 mm, P 0.03; , 0.70, P 0.03; and , 0.91 P 0.01, respectively), per 1 SD increase in 25-OH D (SD 20 nmol/L) at baseline. In longitudinal analyses, vitamin D levels at baseline were not significantly associated with change in LV geometry and function after 5 years. In our community-based study among the elderly, we found higher circulating vitamin D concentrations to be associated cross-sectionally with better LV systolic function and smaller LVESD at baseline. The association persisted after adjusting for several potential confounders, including cardiovascular risk factors and calcium, phosphate, and parathyroid hormone levels. Randomized clinical trials are needed to establish firmly or refute a causal relationship between vitamin D levels and changes in LV geometry and function. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Vitamin D | |
653 | a Cardiovascular disease | |
653 | a Biomarker | |
653 | a Echocardiography | |
653 | a Hälsa och välfärd | |
700 | 1 | a Shiue, Ivyu Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Sweden4 aut |
700 | 1 | a af Geijerstam, Per Bergeau Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Sweden4 aut |
700 | 1 | a Sundström, Johanu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)johasund |
700 | 1 | a Ärnlöv, Johanu Högskolan Dalarna,Uppsala universitet,Geriatrik,School of Health and Social Studies, Dalarna University, Falun, Sweden,Medicinsk vetenskap4 aut0 (Swepub:du)jan |
700 | 1 | a Larsson, Andersu Uppsala universitet,Biokemisk struktur och funktion4 aut0 (Swepub:uu)andlarss |
700 | 1 | a Melhus, Håkanu Uppsala universitet,Klinisk farmakogenomik och osteoporos4 aut0 (Swepub:uu)hakamelh |
700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Ingelsson, Eriku Karolinska Institutet4 aut0 (Swepub:uu)ering425 |
710 | 2 | a Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Swedenb Kardiovaskulär epidemiologi4 org |
773 | 0 | t European Journal of Heart Failured : Wileyg 14:9, s. 985-991q 14:9<985-991x 1388-9842x 1879-0844 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/eurjhf/hfs091 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182007 |
856 | 4 8 | u https://doi.org/10.1093/eurjhf/hfs091 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125125064 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-10573 |
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