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Amplitude-Integrate...
Amplitude-Integrated Electroencephalography in Newborns with Inborn Errors of Metabolism
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Olischar, Monika (author)
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Shany, Eilon (author)
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Aygun, Canan (author)
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Azzopardi, Denis (author)
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Hunt, Rod W. (author)
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Toet, Mona C. (author)
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Hamosh, Ada (author)
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de Vries, Linda S. (author)
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- Hellström-Westas, Lena (author)
- Uppsala universitet,Pediatrik
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Theda, Christiane (author)
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(creator_code:org_t)
- 2012-07-12
- 2012
- English.
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In: Neonatology. - : S. Karger AG. - 1661-7800 .- 1661-7819. ; 102:3, s. 203-211
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The utility of amplitude-integrated electroencephalography (aEEG) monitoring has been established for patients with neonatal hypoxic-ischemic encephalopathy.Objective: To evaluate the role of aEEG in the diagnostic process and treatment of patients with encephalopathy due to inborn errors of metabolism. Methods: Cases collected through an international registry were divided into 5 groups of metabolic disorders. Common aEEG features were sought for each group.Results: In total, 21/30 (70%) cases had abnormal aEEG background patterns, 18/30 (60%) showed seizure activity. Patients with disorders of energy metabolism, hyperammonemia, and organic/amino acidopathies often showed marked aEEG depression with seizure activity. In contrast, aEEGs of patients with peroxisomal disorders did not show major background abnormalities but seizures were present in 5/6 subjects. We report two features of interest: firstly, two tracings displayed an unusual upward shift of the lower aEEG amplitude margin. Secondly, aEEGs of infants with non-ketotic hyperglycinemia showed a pattern we refer to as 'high-frequency burst-suppression pattern'.Conclusions: aEEG in patients with inborn errors of metabolism frequently reveals abnormalities and assists clinicians in the clinical assessment, management and monitoring of these patients.
Keyword
- Electroencephalography
- Amplitude integrated electroencephalography
- Inborn errors of metabolism
- Newborn
- Metabolic disorders
- Neonate
- Cerebral function monitoring
Publication and Content Type
- ref (subject category)
- art (subject category)
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