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Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
- Article/chapterEnglish2006
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-18240
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-18240URI
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https://doi.org/10.1107/S0907444906030915DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1942409URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The Structural Proteomics In Europe (SPINE) programme is aimed at the development and implementation of high-throughput technologies for the efficient structure determination of proteins of biomedical importance, such as those of bacterial and viral pathogens linked to human health. Despite the challenging nature of some of these targets, 175 novel pathogen protein structures (approximately 220 including complexes) have been determined to date. Here the impact of several technologies on the structural determination of proteins from human pathogens is illustrated with selected examples, including the parallel expression of multiple constructs, the use of standardized refolding protocols and optimized crystallization screens.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Alzari, P.
(author)
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Bahar, M.
(author)
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Bertini, I.
(author)
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Betton, J. M.
(author)
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Burmeister, W. P.
(author)
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Cambillau, C.
(author)
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Canard, B.
(author)
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Carrondo, M.
(author)
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Coll, M.
(author)
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Daenke, S.
(author)
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Dym, O.
(author)
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Egloff, M. P.
(author)
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Enguita, F. J.
(author)
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Geerlof, A.
(author)
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Haouz, A.
(author)
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Jones, T. AlwynUppsala universitet,Strukturell molekylärbiologi
(author)
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Ma, Qingjun
(author)
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Manicka, S. N.
(author)
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Migliardi, M.
(author)
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Nordlund, P.Karolinska Institutet
(author)
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Owens, R. J.
(author)
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Peleg, Y.
(author)
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Schneider, G.Karolinska Institutet
(author)
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Schnell, R.Karolinska Institutet
(author)
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Stuart, D. I.
(author)
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Tarbouriech, N.
(author)
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Unge, TorstenUppsala universitet,Strukturell molekylärbiologi
(author)
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Wilkinson, A. J.
(author)
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Wilmanns, M.
(author)
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Wilson, K. S.
(author)
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Zimhony, O.
(author)
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Grimes, J. M.
(author)
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Uppsala universitetStrukturell molekylärbiologi
(creator_code:org_t)
Related titles
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In:Acta Crystallographica Section D62:10, s. 1196-12070907-44491399-0047
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- By the author/editor
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Fogg, M. J.
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Alzari, P.
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Bahar, M.
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Bertini, I.
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Betton, J. M.
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Burmeister, W. P ...
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show more...
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Cambillau, C.
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Canard, B.
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Carrondo, M.
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Coll, M.
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Daenke, S.
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Dym, O.
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Egloff, M. P.
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Enguita, F. J.
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Geerlof, A.
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Haouz, A.
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Jones, T. Alwyn
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Ma, Qingjun
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Manicka, S. N.
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Migliardi, M.
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Nordlund, P.
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Owens, R. J.
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Peleg, Y.
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Schneider, G.
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Schnell, R.
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Stuart, D. I.
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Tarbouriech, N.
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Unge, Torsten
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Wilkinson, A. J.
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Wilmanns, M.
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Wilson, K. S.
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Zimhony, O.
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Grimes, J. M.
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biochemistry and ...
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Acta Crystallogr ...
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Uppsala University
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Karolinska Institutet