Gene expression in spider appendages reveals reversal of exd/hth spatial specificity, altered leg gap gene dynamics, and suggests divergent distal morphogen signaling

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-182609" > Gene expression in ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Prpic, Nikola-MichaelUniversität zu Köln (author)

Gene expression in spider appendages reveals reversal of exd/hth spatial specificity, altered leg gap gene dynamics, and suggests divergent distal morphogen signaling

Article/chapterEnglish2003

Publisher, publication year, extent ...

2003
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-182609
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182609URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Leg development in Drosophila has been studied in much detail. However, Drosophila limbs form in the larva as imaginal discs and not during embryogenesis as in most other arthropods. Here, we analyze appendage genes in the spider Cupiennius salei and the beetle Tribolium castaneum. Differences in decapentaplegic (dpp) expression suggest a different mode of distal morphogen signaling suitable for the specific geometry of growing limb buds. Also, expression of the proximal genes homothorax (hth) and extradenticle (exd) is significantly altered: in the spider, exd is restricted to the proximal leg and hth expression extends distally, while in insects, exd is expressed in the entire leg and hth is restricted to proximal parts. This reversal of spatial specificity demonstrates an evolutionary shift, which is nevertheless compatible with a conserved role of this gene pair as instructor of proximal fate. Different expression dynamics of dachshund and Distal-less point to modifications in the regulation of the leg gap gene system. We comment on the significance of this finding for attempts to homologize leg segments in different arthropod classes. Comparison of the expression profiles of H15 and optomotor-blind to the Drosophila patterns suggests modifications also in the dorsal—ventral patterning system of the legs. Together, our results suggest alterations in many components of the leg developmental system, namely proximal—distal and dorsal—ventral patterning, and leg segmentation. Thus, the leg developmental system exhibits a propensity to evolutionary change, which probably forms the basis for the impressive diversity of arthropod leg morphologies.

Subject headings and genre

NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Janssen, RalfUniversität zu Köln(Swepub:uu)ralja876 (author)
Wigand, BarbaraUniversität München (author)
Klingler, MartinUniversität München (author)
Damen, WiimUniversität zu Köln (author)
Universität zu KölnUniversität München (creator_code:org_t)

Related titles

In:Developmental Biology, s. 119-1400012-16061095-564X

Internet link

https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182609

Find in a library

Developmental Biology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Prpic, Nikola-Mi ...; Janssen, Ralf; Wigand, Barbara; Klingler, Martin; Damen, Wiim

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Genetics

Articles in the publication: Developmental Bi ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se