Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

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Scott, Robert A. (author)

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Article/chapterEnglish2012

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2012-08-12
Springer Science and Business Media LLC,2012
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LIBRIS-ID:oai:DiVA.org:uu-182772
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182772URI
https://doi.org/10.1038/ng.2385DOI
https://lup.lub.lu.se/record/3139506URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:125253560URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60519URI

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Language:English
Summary in:English

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De fem sista författarna delar sistaförfattarskapet.
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.

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Lagou, Vasiliki (author)
Welch, Ryan P. (author)
Wheeler, Eleanor (author)
Montasser, May E. (author)
Luan, Jian'an (author)
Maegi, Reedik (author)
Strawbridge, Rona J.Karolinska Institutet (author)
Rehnberg, Emil (author)
Gustafsson, Stefan (author)
Kanoni, Stavroula (author)
Rasmussen-Torvik, Laura J. (author)
Yengo, Loic (author)
Lecoeur, Cecile (author)
Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Institutionen för odontologi,Medicin(Swepub:umu)dmsh0003 (author)
Sanna, Serena (author)
Sidore, Carlo (author)
Johnson, Paul C. D. (author)
Jukema, J. Wouter (author)
Johnson, Toby (author)
Mahajan, Anubha (author)
Verweij, Niek (author)
Thorleifsson, Gudmar (author)
Hottenga, Jouke-Jan (author)
Shah, Sonia (author)
Smith, Albert V. (author)
Sennblad, BengtKarolinska Institutet (author)
Gieger, Christian (author)
Salo, Perttu (author)
Perola, Markus (author)
Timpson, Nicholas J. (author)
Evans, David M. (author)
St Pourcain, Beate (author)
Wu, Ying (author)
Andrews, Jeanette S. (author)
Hui, Jennie (author)
Bielak, Lawrence F. (author)
Zhao, Wei (author)
Horikoshi, Momoko (author)
Navarro, Pau (author)
Isaacs, Aaron (author)
O'Connell, Jeffrey R. (author)
Stirrups, Kathleen (author)
V Varga, TiborLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)med-tv_ (author)
Hayward, Caroline (author)
Esko, Tonu (author)
Mihailov, Evelin (author)
Fraser, Ross M. (author)
Fall, Tove,1979-Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)tovfa878 (author)
Voight, Benjamin F. (author)
Raychaudhuri, Soumya (author)
Chen, Han (author)
Lindgren, Cecilia M. (author)
Morris, Andrew P. (author)
Rayner, Nigel W. (author)
Robertson, Neil (author)
Rybin, Denis (author)
Liu, Ching-Ti (author)
Beckmann, Jacques S. (author)
Willems, Sara M. (author)
Chines, Peter S. (author)
Jackson, Anne U. (author)
Kang, Hyun Min (author)
Stringham, Heather M. (author)
Song, Kijoung (author)
Tanaka, Toshiko (author)
Peden, John F. (author)
Goel, Anuj (author)
Hicks, Andrew A. (author)
An, Ping (author)
Mueller-Nurasyid, Martina (author)
Franco-Cereceda, AndersKarolinska Institutet (author)
Folkersen, Lasse (author)
Marullo, Letizia (author)
Jansen, Hanneke (author)
Oldehinkel, Albertine J. (author)
Bruinenberg, Marcel (author)
Pankow, James S. (author)
North, Kari E. (author)
Forouhi, Nita G. (author)
Loos, Ruth J. F. (author)
Edkins, Sarah (author)
Varga, Tibor V. (author)
Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Oksa, Heikki (author)
Antonella, Mulas (author)
Nagaraja, Ramaiah (author)
Trompet, Stella (author)
Ford, Ian (author)
Lind, LarsKarolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Kong, Augustine (author)
Kumari, Meena (author)
Gigante, BrunaKarolinska Institutet (author)
Herder, Christian (author)
Munroe, Patricia B. (author)
Caulfield, Mark (author)
Antti, Jula (author)
Mangino, Massimo (author)
Small, Kerrin (author)
Miljkovic, Iva (author)
Liu, Yongmei (author)
Atalay, Mustafa (author)
Kiess, Wieland (author)
James, Alan L. (author)
Rivadeneira, Fernando (author)
Uitterlinden, Andre G. (author)
Palmer, Colin N. A. (author)
Doney, Alex S. F. (author)
Willemsen, Gonneke (author)
Smit, Johannes H. (author)
Campbell, Susan (author)
Polasek, Ozren (author)
Bonnycastle, Lori L. (author)
Hercberg, Serge (author)
Dimitriou, Maria (author)
Bolton, Jennifer L. (author)
Fowkes, Gerard R. (author)
Kovacs, PeterKarolinska Institutet (author)
Lindstrom, Jaana (author)
Zemunik, Tatijana (author)
Bandinelli, Stefania (author)
Wild, Sarah H. (author)
Basart, Hanneke V. (author)
Rathmann, Wolfgang (author)
Grallert, Harald (author)
Maerz, Winfried (author)
Kleber, Marcus E. (author)
Boehm, Bernhard O. (author)
Peters, Annette (author)
Pramstaller, Peter P. (author)
Province, Michael A. (author)
Borecki, Ingrid B. (author)
Hastie, Nicholas D. (author)
Rudan, Igor (author)
Campbell, Harry (author)
Watkins, Hugh (author)
Farrall, Martin (author)
Stumvoll, Michael (author)
Ferrucci, Luigi (author)
Waterworth, Dawn M. (author)
Bergman, Richard N. (author)
Collins, Francis S. (author)
Tuomilehto, Jaakko (author)
Watanabe, Richard M. (author)
de Geus, Eco J. C. (author)
Penninx, Brenda W. (author)
Hofman, Albert (author)
Oostra, Ben A. (author)
Psaty, Bruce M. (author)
Vollenweider, Peter (author)
Wilson, James F. (author)
Wright, Alan F. (author)
Hovingh, G. Kees (author)
Metspalu, Andres (author)
Uusitupa, Matti (author)
Magnusson, Patrik K. E. (author)
Kyvik, Kirsten O. (author)
Kaprio, Jaakko (author)
Price, Jackie F. (author)
Dedoussis, George V. (author)
Deloukas, Panos (author)
Meneton, Pierre (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Boehnke, Michael (author)
Shuldiner, Alan R. (author)
van Duijn, Cornelia M. (author)
Morris, Andrew D. (author)
Toenjes, Anke (author)
Peyser, Patricia A. (author)
Beilby, John P. (author)
Koerner, Antje (author)
Kuusisto, Johanna (author)
Laakso, Markku (author)
Bornstein, Stefan R. (author)
Schwarz, Peter E. H. (author)
Lakka, Timo A. (author)
Rauramaa, Rainer (author)
Adair, Linda S. (author)
Smith, George Davey (author)
Spector, Tim D. (author)
Illig, Thomas (author)
de Faire, UlfKarolinska Institutet (author)
Hamsten, AndersKarolinska Institutet (author)
Gudnason, Vilmundur (author)
Kivimaki, Mika (author)
Hingorani, Aroon (author)
Keinanen-Kiukaanniemi, Sirkka M. (author)
Saaristo, Timo E. (author)
Boomsma, Dorret I. (author)
Stefansson, Kari (author)
van der Harst, Pim (author)
Dupuis, Josee (author)
Pedersen, Nancy L. (author)
Sattar, Naveed (author)
Harris, Tamara B. (author)
Cucca, Francesco (author)
Ripatti, Samuli (author)
Salomaa, Veikko (author)
Mohlke, Karen L. (author)
Balkau, Beverley (author)
Froguel, Philippe (author)
Pouta, Anneli (author)
Jarvelin, Marjo-Riitta (author)
Wareham, Nicholas J. (author)
Bouatia-Naji, Nabila (author)
McCarthy, Mark I. (author)
Franks, PaulUmeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Medicin(Swepub:umu)pafr0003 (author)
Meigs, James B. (author)
Teslovich, Tanya M. (author)
Florez, Jose C. (author)
Langenberg, Claudia (author)
Ingelsson, ErikKarolinska Institutet (author)
Prokopenko, Inga (author)
Barroso, Ines (author)
Karolinska InstitutetInstitutionen för kliniska vetenskaper, Malmö (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC44:9, s. 991-10051061-40361546-1718

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By the author/editor: Scott, Robert A.; Lagou, Vasiliki; Welch, Ryan P.; Wheeler, Eleanor; Montasser, May E ...; Luan, Jian'an; show more...; Maegi, Reedik; Strawbridge, Ron ...; Rehnberg, Emil; Gustafsson, Stef ...; Kanoni, Stavroul ...; Rasmussen-Torvik ...; Yengo, Loic; Lecoeur, Cecile; Shungin, Dmitry; Sanna, Serena; Sidore, Carlo; Johnson, Paul C. ...; Jukema, J. Woute ...; Johnson, Toby; Mahajan, Anubha; Verweij, Niek; Thorleifsson, Gu ...; Hottenga, Jouke- ...; Shah, Sonia; Smith, Albert V.; Sennblad, Bengt; Gieger, Christia ...; Salo, Perttu; Perola, Markus; Timpson, Nichola ...; Evans, David M.; St Pourcain, Bea ...; Wu, Ying; Andrews, Jeanett ...; Hui, Jennie; Bielak, Lawrence ...; Zhao, Wei; Horikoshi, Momok ...; Navarro, Pau; Isaacs, Aaron; O'Connell, Jeffr ...; Stirrups, Kathle ...; V Varga, Tibor; Hayward, Carolin ...; Esko, Tonu; Mihailov, Evelin; Fraser, Ross M.; Fall, Tove, 1979 ...; Voight, Benjamin ...; Raychaudhuri, So ...; Chen, Han; Lindgren, Cecili ...; Morris, Andrew P ...; Rayner, Nigel W.; Robertson, Neil; Rybin, Denis; Liu, Ching-Ti; Beckmann, Jacque ...; Willems, Sara M.; Chines, Peter S.; Jackson, Anne U.; Kang, Hyun Min; Stringham, Heath ...; Song, Kijoung; Tanaka, Toshiko; Peden, John F.; Goel, Anuj; Hicks, Andrew A.; An, Ping; Mueller-Nurasyid ...; Franco-Cereceda, ...; Folkersen, Lasse; Marullo, Letizia; Jansen, Hanneke; Oldehinkel, Albe ...; Bruinenberg, Mar ...; Pankow, James S.; North, Kari E.; Forouhi, Nita G.; Loos, Ruth J. F.; Edkins, Sarah; Varga, Tibor V.; Hallmans, Göran, ...; Oksa, Heikki; Antonella, Mulas; Nagaraja, Ramaia ...; Trompet, Stella; Ford, Ian; Lind, Lars; Kong, Augustine; Kumari, Meena; Gigante, Bruna; Herder, Christia ...; Munroe, Patricia ...; Caulfield, Mark; Antti, Jula; Mangino, Massimo; Small, Kerrin; Miljkovic, Iva; Liu, Yongmei; Atalay, Mustafa; Kiess, Wieland; James, Alan L.; Rivadeneira, Fer ...; Uitterlinden, An ...; Palmer, Colin N. ...; Doney, Alex S. F ...; Willemsen, Gonne ...; Smit, Johannes H ...; Campbell, Susan; Polasek, Ozren; Bonnycastle, Lor ...; Hercberg, Serge; Dimitriou, Maria; Bolton, Jennifer ...; Fowkes, Gerard R ...; Kovacs, Peter; Lindstrom, Jaana; Zemunik, Tatijan ...; Bandinelli, Stef ...; Wild, Sarah H.; Basart, Hanneke ...; Rathmann, Wolfga ...; Grallert, Harald; Maerz, Winfried; Kleber, Marcus E ...; Boehm, Bernhard ...; Peters, Annette; Pramstaller, Pet ...; Province, Michae ...; Borecki, Ingrid ...; Hastie, Nicholas ...; Rudan, Igor; Campbell, Harry; Watkins, Hugh; Farrall, Martin; Stumvoll, Michae ...; Ferrucci, Luigi; Waterworth, Dawn ...; Bergman, Richard ...; Collins, Francis ...; Tuomilehto, Jaak ...; Watanabe, Richar ...; de Geus, Eco J. ...; Penninx, Brenda ...; Hofman, Albert; Oostra, Ben A.; Psaty, Bruce M.; Vollenweider, Pe ...; Wilson, James F.; Wright, Alan F.; Hovingh, G. Kees; Metspalu, Andres; Uusitupa, Matti; Magnusson, Patri ...; Kyvik, Kirsten O ...; Kaprio, Jaakko; Price, Jackie F.; Dedoussis, Georg ...; Deloukas, Panos; Meneton, Pierre; Boehnke, Michael; Shuldiner, Alan ...; van Duijn, Corne ...; Morris, Andrew D ...; Toenjes, Anke; Peyser, Patricia ...; Beilby, John P.; Koerner, Antje; Kuusisto, Johann ...; Laakso, Markku; Bornstein, Stefa ...; Schwarz, Peter E ...; Lakka, Timo A.; Rauramaa, Rainer; Adair, Linda S.; Smith, George Da ...; Spector, Tim D.; Illig, Thomas; de Faire, Ulf; Hamsten, Anders; Gudnason, Vilmun ...; Kivimaki, Mika; Hingorani, Aroon; Keinanen-Kiukaan ...; Saaristo, Timo E ...; Boomsma, Dorret ...; Stefansson, Kari; van der Harst, P ...; Dupuis, Josee; Pedersen, Nancy ...; Sattar, Naveed; Harris, Tamara B ...; Cucca, Francesco; Ripatti, Samuli; Salomaa, Veikko; Mohlke, Karen L.; Balkau, Beverley; Froguel, Philipp ...; Pouta, Anneli; Jarvelin, Marjo- ...; Wareham, Nichola ...; Bouatia-Naji, Na ...; McCarthy, Mark I ...; Franks, Paul; Meigs, James B.; Teslovich, Tanya ...; Florez, Jose C.; Langenberg, Clau ...; Ingelsson, Erik; Prokopenko, Inga; Barroso, Ines; show less...

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