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Bone tissue composi...
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Lind, MonicaUppsala universitet,Institutionen för evolutionsbiologi
(author)
Bone tissue composition, dimensions and strength in female rats given an increased dietary level of vitamin A or exposed to 3,3',4, 4',5-pentachlorobiphenyl (PCB126) alone or in combination with vitamin C.
- Article/chapterEnglish2000
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-18463
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-18463URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In previous studies we have described structural and functional changes in rat bone tissue caused by 3,3',4,4',5-pentachlorobiphenyl (PCB126). Some of the effects caused by PCB126 resemble those found in vitamin C-deficient rats, as well as those found in rats with a high dietary intake of vitamin A. The present investigation was designed to determine if these PCB126-induced changes could be inhibited by addition of vitamin C to the drinking water and if they could be evoked by vitamin A administration. Five groups of female rats were used in this study, which lasted for 12 weeks. Three of the groups were exposed to PCB126 (total dose 320 microgram/kg, bw), either alone or in combination with vitamin C added to the drinking water (1 and 10 g/l, respectively). One group was given feed with increased level of vitamin A (600000 U/kg pellet) and the fifth group served as controls. Using peripheral quantitative computed tomography (pQCT), it was found that PCB126 increased trabecular density and cortical thickness, but reduced the trabecular area. Furthermore, maximum torque and stiffness of the humerus during torsional testing and serum osteocalcin levels were reduced by PCB126. Of the PCB126 induced effects observed, addition of vitamin C only inhibited the reduction of serum osteocalcin. Like PCB126 vitamin A supplementation increased the inorganic content and the bone density and also reduced the trabecular area and polar moment of inertia but did not increase the cortical thickness or reduce maximum torque, stiffness or serum osteocalcin level. Apparently, the effects induced by PCB126 are not mediated either via decreased vitamin C level or increased vitamin A level.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
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MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
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Animals
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Ascorbic Acid/*pharmacology
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Body Weight/drug effects
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Bone and Bones/anatomy & histology/*drug effects/metabolism
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Diaphyses/anatomy & histology/drug effects/metabolism
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Diet
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Epiphyses/anatomy & histology/drug effects/metabolism
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Estrogen Antagonists/*toxicity
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Female
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Humerus/anatomy & histology/drug effects/metabolism
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Organ Size/drug effects
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Osteocalcin/pharmacology
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Polychlorinated Biphenyls/*toxicity
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Rats
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Rats; Sprague-Dawley
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Tomography; X-Ray Computed
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Vitamin A/*pharmacology
Added entries (persons, corporate bodies, meetings, titles ...)
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Larsson, S
(author)
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Johansson, S
(author)
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Melhus, H
(author)
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Wikström, M
(author)
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Lindhe, ÖUppsala universitet,Ekotoxikologi
(author)
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Örberg, JUppsala universitet,Ekotoxikologi
(author)
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Uppsala universitetInstitutionen för evolutionsbiologi
(creator_code:org_t)
Related titles
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In:Toxicology151:1-3, s. 11-230300-483X1879-3185
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