Bone tissue composition, dimensions and strength in female rats given an increased dietary level of vitamin A or exposed to 3,3',4, 4',5-pentachlorobiphenyl (PCB126) alone or in combination with vitamin C.

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Lind, MonicaUppsala universitet,Institutionen för evolutionsbiologi (author)

Bone tissue composition, dimensions and strength in female rats given an increased dietary level of vitamin A or exposed to 3,3',4, 4',5-pentachlorobiphenyl (PCB126) alone or in combination with vitamin C.

Article/chapterEnglish2000

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2000
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LIBRIS-ID:oai:DiVA.org:uu-18463
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-18463URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

In previous studies we have described structural and functional changes in rat bone tissue caused by 3,3',4,4',5-pentachlorobiphenyl (PCB126). Some of the effects caused by PCB126 resemble those found in vitamin C-deficient rats, as well as those found in rats with a high dietary intake of vitamin A. The present investigation was designed to determine if these PCB126-induced changes could be inhibited by addition of vitamin C to the drinking water and if they could be evoked by vitamin A administration. Five groups of female rats were used in this study, which lasted for 12 weeks. Three of the groups were exposed to PCB126 (total dose 320 microgram/kg, bw), either alone or in combination with vitamin C added to the drinking water (1 and 10 g/l, respectively). One group was given feed with increased level of vitamin A (600000 U/kg pellet) and the fifth group served as controls. Using peripheral quantitative computed tomography (pQCT), it was found that PCB126 increased trabecular density and cortical thickness, but reduced the trabecular area. Furthermore, maximum torque and stiffness of the humerus during torsional testing and serum osteocalcin levels were reduced by PCB126. Of the PCB126 induced effects observed, addition of vitamin C only inhibited the reduction of serum osteocalcin. Like PCB126 vitamin A supplementation increased the inorganic content and the bone density and also reduced the trabecular area and polar moment of inertia but did not increase the cortical thickness or reduce maximum torque, stiffness or serum osteocalcin level. Apparently, the effects induced by PCB126 are not mediated either via decreased vitamin C level or increased vitamin A level.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
Animals
Ascorbic Acid/*pharmacology
Body Weight/drug effects
Bone and Bones/anatomy & histology/*drug effects/metabolism
Diaphyses/anatomy & histology/drug effects/metabolism
Diet
Epiphyses/anatomy & histology/drug effects/metabolism
Estrogen Antagonists/*toxicity
Female
Humerus/anatomy & histology/drug effects/metabolism
Organ Size/drug effects
Osteocalcin/pharmacology
Polychlorinated Biphenyls/*toxicity
Rats
Rats; Sprague-Dawley
Tomography; X-Ray Computed
Vitamin A/*pharmacology

Added entries (persons, corporate bodies, meetings, titles ...)

Larsson, S (author)
Johansson, S (author)
Melhus, H (author)
Wikström, M (author)
Lindhe, ÖUppsala universitet,Ekotoxikologi (author)
Örberg, JUppsala universitet,Ekotoxikologi (author)
Uppsala universitetInstitutionen för evolutionsbiologi (creator_code:org_t)

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In:Toxicology151:1-3, s. 11-230300-483X1879-3185

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By the author/editor: Lind, Monica; Larsson, S; Johansson, S; Melhus, H; Wikström, M; Lindhe, Ö; show more...; Örberg, J; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine

Articles in the publication: Toxicology

By the university: Uppsala University

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