Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

• Evidence supporting the action of passive diffusion and carrier-mediated (CM) transport in drug bioavailability and disposition is discussed to refute the recently proposed theory that drug transport is CM-only and that new transporters will be discovered that possess transport characteristics ascribed to passive diffusion. Misconceptions and faulty speculations are addressed to provide reliable guidance on choosing appropriate tools for drug design and optimization.

Keyword

membrane permeation assay

central-nervous-system

pept1 knockout mice

neutral amino-acid

lipid-bilayers

p-glycoprotein

artificial membranes

hydrophilic pores

transient pores

caco-2 cells

Publication and Content Type

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