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PPARβ/δ affects pan...
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice
- Article/chapterEnglish2012
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-185266
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185266URI
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https://doi.org/10.1172/JCI42127DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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PPARβ/δ protects against obesity by reducing dyslipidemia and insulin resistance via effects in muscle, adipose tissue, and liver. However, its function in pancreas remains ill defined. To gain insight into its hypothesized role in β cell function, we specifically deleted Pparb/d in the epithelial compartment of the mouse pancreas. Mutant animals presented increased numbers of islets and, more importantly, enhanced insulin secretion, causing hyperinsulinemia. Gene expression profiling of pancreatic β cells indicated a broad repressive function of PPARβ/δ affecting the vesicular and granular compartment as well as the actin cytoskeleton. Analyses of insulin release from isolated PPARβ/δ-deficient islets revealed an accelerated second phase of glucose-stimulated insulin secretion. These effects in PPARβ/δ-deficient islets correlated with increased filamentous actin (F-actin) disassembly and an elevation in protein kinase D activity that altered Golgi organization. Taken together, these results provide evidence for a repressive role for PPARβ/δ in β cell mass and insulin exocytosis, and shed a new light on PPARβ/δ metabolic action.
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Barg, Sebastian,1969-Uppsala universitet,Institutionen för medicinsk cellbiologi,Barg(Swepub:uu)sebba507
(author)
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Vallois, David
(author)
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Lahiri, Shawon
(author)
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Roger, Catherine
(author)
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Yessoufou, Akadiri
(author)
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Pradevand, Sylvain
(author)
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McDonald, Angela
(author)
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Bonal, Claire
(author)
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Reimann, Frank
(author)
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Gribble, Fiona
(author)
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Debril, Marie-Bernard
(author)
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Metzger, Daniel
(author)
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Chambon, Pierre
(author)
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Herrera, Pedro
(author)
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Rutter, Guy A
(author)
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Prentki, Marc
(author)
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Thorens, Bernard
(author)
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Wahli, Walter
(author)
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Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Related titles
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In:Journal of Clinical Investigation122:11, s. 4105-41170021-97381558-8238
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Iglesias, José
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Barg, Sebastian, ...
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Vallois, David
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Lahiri, Shawon
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Roger, Catherine
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Yessoufou, Akadi ...
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Pradevand, Sylva ...
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McDonald, Angela
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Bonal, Claire
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Reimann, Frank
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Gribble, Fiona
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Debril, Marie-Be ...
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Metzger, Daniel
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Chambon, Pierre
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Herrera, Pedro
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Rutter, Guy A
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Prentki, Marc
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Thorens, Bernard
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Wahli, Walter
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Journal of Clini ...
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Uppsala University