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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003144naa a2200385 4500
001oai:DiVA.org:uu-185482
003SwePub
008121126s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:125472197
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1854822 URI
0247 a https://doi.org/10.1128/JCM.01713-122 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1254721972 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Christerson, Linusu Uppsala universitet,Klinisk bakteriologi4 aut
2451 0a Chlamydia trachomatis Strains Show Specific Clustering for Men Who Have Sex with Men Compared to Heterosexual Populations in Sweden, the Netherlands, and the United States
264 1c 2012
338 a print2 rdacarrier
520 a High-resolution genotyping of Chlamydia trachomatis improves the characterization of strains infecting different patient groups and sexual networks. In this study, multilocus sequence typing (MLST) and ompA sequence determination were used for an analysis of C. trachomatis strains from 203 men who have sex with men (MSM) from Sweden, the Netherlands, and the United States. The results obtained were compared with data from 153 heterosexual women from Sweden and the Netherlands. The overlap in MLST/ompA profiles between MSM from Sweden and the Netherlands was 68%, while the overlap between heterosexual populations from these countries was only 18%. The distribution of genotypes in MSM from the United States was less similar to that in MSM from the European countries, with 45% and 46% overlaps for MSM in Sweden and the Netherlands, respectively. Minimum-spanning-tree analysis of MLST/ompA sequence types identified two large clusters that contained almost exclusively samples from MSM and comprised 74% of all MSM samples. Three other clusters were predominated by samples from women but also contained MSM specimens. Of 19 detected variants of the MLST target CT144, three variants were highly associated with MSM. Our study supports the hypotheses of both tissue tropism as well as epidemiological network structures as explanations for the linkage between specific genetic variants and sexual orientation.
7001 a Bom, Reinier J. M.4 aut
7001 a Bruisten, Sylvia M.4 aut
7001 a Yass, Reshau Uppsala universitet,Klinisk bakteriologi4 aut
7001 a Hardick, Justin4 aut
7001 a Bratt, Goranu Karolinska Institutet4 aut
7001 a Gaydos, Charlotte A.4 aut
7001 a Morre, Servaas A.4 aut
7001 a Herrmann, Bjornu Uppsala universitet,Klinisk bakteriologi4 aut0 (Swepub:uu)bjorherr
7102 a Uppsala universitetb Klinisk bakteriologi4 org
7730 t Journal of Clinical Microbiologyg 50:11, s. 3548-3555q 50:11<3548-3555x 0095-1137x 1098-660X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185482
8564 8u https://doi.org/10.1128/JCM.01713-12
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125472197

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