Validation of questionnaire-based long-term dietary exposure to polychlorinated biphenyls using biomarkers

Scope The health consequences of lifelong low-level exposure to polychlorinated biphenyls (PCBs) via food are largely unknown, mainly due to the lack of large population-based prospective studies addressing this issue. We validated long-term food frequency questionnaire (FFQ)-based dietary PCB exposure against concentrations of six PCB congeners in serum. Methods and results Dietary PCB exposure was estimated in the Swedish Mammography Cohort by constructing a recipe-based database of CB-153, an indicator for total PCBs in food. The Spearman rank correlation (adjusted for within-person variability) was assessed between concurrent (20042006), past (1997), and long-term (mean of 1997 and 20042006) FFQ-based dietary PCB exposure, respectively, and the following serum PCB congeners, CB-118, CB-138, CB-153, CB-156, CB-170, and CB-180, in women (5685 years of age, n = 201). The correlation between FFQ-based dietary PCB exposure and serum CB-153 was 0.41 (p < 0.001) for the concurrent (median 1.6 ng/kg body weight) and 0.34 (p < 0.05) for the past (median 2.6 ng/kg body weight) exposure assessment. Long-term validity of FFQ-based PCB estimates and the six serum PCB congeners ranged from 0.30 to 0.58 (p < 0.05). Conclusion FFQ-based PCB exposure estimates show acceptable validity in relation to PCB concentrations in serum, justifying their use in large-scale epidemiological studies.

Åkesson, AgnetaKarolinska Institutet (author)
Glynn, Anders (author)
Michaëlsson, KarlUppsala universitet,Ortopedi(Swepub:uu)karlmich (author)
Rantakokko, PanuUppsala universitet,Institutionen för kirurgiska vetenskaper (author)
Kiviranta, HannuUppsala universitet,Institutionen för kirurgiska vetenskaper (author)
Wolk, Alicja (author)
Berglund, MarikaKarolinska Institutet (author)
Karolinska InstitutetOrtopedi (creator_code:org_t)

In:Molecular Nutrition & Food Research: Wiley56:11, s. 1748-17541613-41251613-4133

By the author/editor: Bergkvist, Charl ...; Åkesson, Agneta; Glynn, Anders; Michaëlsson, Kar ...; Rantakokko, Panu; Kiviranta, Hannu; show more...; Wolk, Alicja; Berglund, Marika; show less...

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