Search: onr:"swepub:oai:DiVA.org:uu-185501" >
Anchored phosphatas...
Anchored phosphatases modulate glucose homeostasis
-
Hinke, Simon A. (author)
-
Navedo, Manuel F. (author)
-
Ulman, Allison (author)
-
show more...
-
Whiting, Jennifer L. (author)
-
Nygren, Patrick J. (author)
-
- Tian, Geng (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
Jimenez-Caliani, Antonio J. (author)
-
Langeberg, Lorene K. (author)
-
Cirulli, Vincenzo (author)
-
- Tengholm, Anders (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
Dell'Acqua, Mark L. (author)
-
Santana, L. Fernando (author)
-
Scott, John D. (author)
-
show less...
-
(creator_code:org_t)
- 2012-08-31
- 2012
- English.
-
In: EMBO Journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 31:20, s. 3991-4004
- Related links:
-
https://europepmc.or...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic beta-cells involves ion channels and mobilization of Ca2+ and cyclic AMP (cAMP) signalling pathways. Whole-animal physiology, islet studies and live-beta-cell imaging approaches reveal that ablation of the kinase/phosphatase anchoring protein AKAP150 impairs insulin secretion in mice. Loss of AKAP150 impacts L-type Ca2+ currents, and attenuates cytoplasmic accumulation of Ca2+ and cAMP in beta-cells. Yet surprisingly AKAP150 null animals display improved glucose handling and heightened insulin sensitivity in skeletal muscle. More refined analyses of AKAP150 knock-in mice unable to anchor protein kinase A or protein phosphatase 2B uncover an unexpected observation that tethering of phosphatases to a seven-residue sequence of the anchoring protein is the predominant molecular event underlying these metabolic phenotypes. Thus anchored signalling events that facilitate insulin secretion and glucose homeostasis may be set by AKAP150 associated phosphatase activity.
Keyword
- A-kinase anchoring protein (AKAP)
- calcineurin (PP2B)
- cyclic-AMP-dependent protein kinase (PKA)
- glucoregulation
- glucose-stimulated insulin secretion (GSIS)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Hinke, Simon A.
-
Navedo, Manuel F ...
-
Ulman, Allison
-
Whiting, Jennife ...
-
Nygren, Patrick ...
-
Tian, Geng
-
show more...
-
Jimenez-Caliani, ...
-
Langeberg, Loren ...
-
Cirulli, Vincenz ...
-
Tengholm, Anders
-
Dell'Acqua, Mark ...
-
Santana, L. Fern ...
-
Scott, John D.
-
show less...
- Articles in the publication
-
EMBO Journal
- By the university
-
Uppsala University