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What model organism...
What model organisms and interactomics can reveal about the genetics of human obesity
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- Williams, Michael J. (author)
- Uppsala universitet,Funktionell farmakologi
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- Almén, Markus Sällman (author)
- Uppsala universitet,Funktionell farmakologi
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- Fredriksson, Robert (author)
- Uppsala universitet,Funktionell farmakologi
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- Schiöth, Helgi B. (author)
- Uppsala universitet,Funktionell farmakologi
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(creator_code:org_t)
- 2012-05-23
- 2012
- English.
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In: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 69:22, s. 3819-3834
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Genome-wide association studies have identified a number of genes associated with human body weight. While some of these genes are large fields within obesity research, such as MC4R, POMC, FTO and BDNF, the majority do not have a clearly defined functional role explaining why they may affect body weight. Here, we searched biological databases and discovered 33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, TUB, ZNF608, FAIM2, KCTD15, LINGO2, POC5, PTBP2, TMEM18, TMEM160). We find that the majority have orthologues in distant species, such as D. melanogaster and C. elegans, suggesting that they are important for the biology of most bilateral species. Intriguingly, signalling cascade genes and transcription factors are enriched among these obesity genes, and several of the genes show properties that could be useful for potential drug discovery. In this review, we demonstrate how information from several distant model species, interactomics and signalling pathway analysis represents an important way to better understand the functional diversity of the surprisingly high number of molecules that seem to be important for human obesity.
Keyword
- C. elegans
- Drosophila
- Genome-wide association studies
- Interactomics
- Signalling cascade genes
Publication and Content Type
- ref (subject category)
- for (subject category)
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