Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat

Gastric mucosal clearance of 51Cr-labeled red blood cells (51Cr-RBC) was measured in rats during a 30-min control period, a 30-min ischemic period (hemorrhage to 27 mmHg arterial pressure), and a 60-min reperfusion period (reinfusion of shed blood). In untreated (control) rats, a dramatic rise in the leakage of 51Cr-labeled red blood cells into the gastric lumen was observed during the reperfusion period. Treatment with neutrophil antiserum attenuated 51Cr-labeled red blood cell flux into the gastric lumen. Using the radioactive microsphere technique, neutrophil-depleted animals were shown to have higher blood flows in the ischemic period than the untreated rats. Bleeding of untreated rats to a mean arterial pressure of 40 mmHg resulted in blood flows that were not different from those in antiserum-treated rats bled to 27 mmHg and leakage of 51Cr-labeled red blood cells similar to that measured in antiserum-treated rats. The results of this study indicate that neutrophils play an important role in hemorrhagic shock-induced gastric bleeding.

Holm-Rutili, LenaUppsala universitet,Integrativ Fysiologi(Swepub:uu)pho23887 (author)
Perry, M A (author)
Grisham, M BUppsala universitet,Integrativ Fysiologi (author)
Arfors, K E (author)
Granger, D N (author)
Kvietys, P R (author)
Uppsala universitetIntegrativ Fysiologi (creator_code:org_t)

By the author/editor: Smith, S M; Holm-Rutili, Len ...; Perry, M A; Grisham, M B; Arfors, K E; Granger, D N; show more...; Kvietys, P R; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

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