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Association between Chlamydia pneumoniae antibodies and wheezing in young children and the influence of sex
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- Normann, Erik (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall
- Gnarpe, J. (author)
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- Wettergren, Björn (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall
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- BMJ, 2006
- 2006
- English.
- In: Thorax. - : BMJ. - 0040-6376 .- 1468-3296. ; 61:12, s. 1054-1058
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND: The proposed association between Chlamydia pneumoniae (Cpn) infection and wheezing needs further clarification. METHODS: Serum samples obtained from 1581 children aged 4 years in a population based cohort were tested for antibodies to Cpn and IgE antibodies to common allergens. Data on environmental factors and disease were collected prospectively from birth. RESULTS: The occurrence of IgG antibodies to Cpn at 4 years of age was associated with reported wheezing at different ages; however, these findings were most often not significant. In girls, the occurrence of anti-Cpn IgG was associated with wheezing at the ages of 1, 2, and 4 years (odds ratios (ORs) 3.41 (95% confidence interval (CI) 1.46 to 7.96), 2.13 (95% CI 1.02 to 4.44), and 2.01 (95% CI 1.14 to 3.54), respectively), and even higher ORs were observed for each age category when only high level antibody responses to Cpn were analysed. At the time of blood sampling the association between anti-Cpn IgG and wheezing was restricted to girls without atopic sensitisation (OR 2.39 (95% CI 1.25 to 4.57). No associations with wheezing were detected in boys, in whom IgE sensitisation was inversely associated with the presence of anti-Cpn IgG (OR 0.49 (95% CI 0.26 to 0.90)). CONCLUSIONS: This study suggests an association between evidence of earlier Cpn infection and a history of wheezing in young girls. Infection with Cpn may be an important risk factor for wheezing and possibly for non-atopic asthma, predominantly in girls.
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