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A Genome-Wide Assoc...
A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol
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Surakka, Ida (author)
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Whitfield, John B (author)
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Perola, Markus (author)
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Visscher, Peter M (author)
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Montgomery, Grant W (author)
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Falchi, Mario (author)
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Willemsen, Gonneke (author)
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de Geus, Eco J C (author)
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- Magnusson, Patrik K E (author)
- Karolinska Institutet
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Christensen, Kaare (author)
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Sørensen, Thorkild I A (author)
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Pietiläinen, Kirsi H (author)
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Rantanen, Taina (author)
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Silander, Kaisa (author)
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Widén, Elisabeth (author)
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Muilu, Juha (author)
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- Rahman, Iffat (author)
- Karolinska Institutet
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Liljedahl, Ulrika (author)
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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Palotie, Aarno (author)
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Kaprio, Jaakko (author)
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Kyvik, Kirsten O (author)
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- Pedersen, Nancy L (author)
- Karolinska Institutet
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Boomsma, Dorret I (author)
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Spector, Tim (author)
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Martin, Nicholas G (author)
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Ripatti, Samuli (author)
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Peltonen, Leena (author)
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(creator_code:org_t)
- 2012-10-03
- 2012
- English.
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In: Twin Research and Human Genetics. - : Cambridge University Press (CUP). - 1832-4274 .- 1839-2628. ; 15:6, s. 691-699
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https://urn.kb.se/re...
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Abstract
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- Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10-8). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03 × 10-8).
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- art (subject category)
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- By the author/editor
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Surakka, Ida
-
Whitfield, John ...
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Perola, Markus
-
Visscher, Peter ...
-
Montgomery, Gran ...
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Falchi, Mario
-
show more...
-
Willemsen, Gonne ...
-
de Geus, Eco J C
-
Magnusson, Patri ...
-
Christensen, Kaa ...
-
Sørensen, Thorki ...
-
Pietiläinen, Kir ...
-
Rantanen, Taina
-
Silander, Kaisa
-
Widén, Elisabeth
-
Muilu, Juha
-
Rahman, Iffat
-
Liljedahl, Ulrik ...
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Syvänen, Ann-Chr ...
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Palotie, Aarno
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Kaprio, Jaakko
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Kyvik, Kirsten O
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Pedersen, Nancy ...
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Boomsma, Dorret ...
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Spector, Tim
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Martin, Nicholas ...
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Ripatti, Samuli
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Peltonen, Leena
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show less...
- Articles in the publication
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Twin Research an ...
- By the university
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Uppsala University
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Karolinska Institutet