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Secondary preventio...
Secondary prevention and risk factor target achievement in a global, high-risk population with established coronary heart disease : baseline results from the STABILITY study
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- Vedin, Ola (author)
- Uppsala universitet,Kardiologi
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- Hagström, Emil (author)
- Uppsala universitet,Kardiologi
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Stewart, Ralph (author)
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Brown, Rebekkah (author)
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Krug-Gourley, Susan (author)
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Davies, Richard (author)
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- Wallentin, Lars (author)
- Uppsala universitet,Kardiologi
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White, Harvey (author)
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- Held, Claes (author)
- Uppsala universitet,Kardiologi
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(creator_code:org_t)
- 2012-04-10
- 2013
- English.
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In: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 20:4, s. 678-685
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Aim:There is limited contemporary data on achievement of risk factor goals for secondary prevention of cardiovascular (CV) disease from countries in many regions of the world. This report describes the global and regional prevalence of CV risk factors and use of preventive medications at baseline in participants in the ongoing STabilization of Atherosclerotic plaque By Initiation of darapLadIb TherapY (STABILITY) trial.Methods and Results:Detailed individual data on CV risk factors were obtained before randomization in 15,828 patients with chronic coronary heart disease (CHD) from 39 countries on five continents. Subjects had a history of myocardial infarction, prior coronary revascularization, or multi-vessel CHD without revascularization and at least one additional CV risk factor. The majority were taking a statin (97%), antiplatelet therapy (96%), beta-blocker (79%), or angiotensin converting enzyme inhibitor/angiotensin receptor blocker (77%). However, a large proportion of patients did not achieve guideline-recommended targets. For instance, in 29% low-density lipoprotein (LDL) cholesterol was >2.5 mmol/l and in 46% blood pressure was ≥140/90 mmHg or ≥130/80 mmHg in those with diabetes or renal impairment. The body mass index was >30 kg/m2 in 36%, waist circumference ≥102 cm for men or ≥88 cm for women in 54%, and 18% were smoking. Regional differences in risk factor prevalence and target achievement were observed and were more marked for LDL cholesterol and obesity.Conclusion:The prevalence of modifiable CV risk factors was generally high in the STABILITY population. Although, most patients were receiving evidence-based secondary preventive therapy many subjects from all regions did not reach recommended secondary prevention goals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- acute coronary syndromes
- anticoagulants
- apixaban
- atrial fibrillation
- dabigatran etexilate
- edoxaban
- rivaroxaban
- vitamin K antagonists
Publication and Content Type
- ref (subject category)
- art (subject category)
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