AT2 Receptor Agonists: Exploiting the Beneficial Arm of Ang II Signaling

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Gallo-Payet, Nicole (author)

AT2 Receptor Agonists : Exploiting the Beneficial Arm of Ang II Signaling

Article/chapterEnglish2012

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bentham science publishers,2012
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LIBRIS-ID:oai:DiVA.org:uu-191000
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-191000URI
https://doi.org/10.2174/157340212800504990DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

Notes

In the classical view, the hormone angiotensin II (Ang II) mediates its action via two major receptors, namely the Ang II type-1 receptor (AT1R) and the type-2 receptor (AT2R). Several recent reviews implicate the renin-angiotensin system (RAS) in various aspects of adipose tissue physiology and dysfunction. Research on AT2R has long been hampered by at least three potential challenges, (i) the low expression level of the AT2R in the adult, (ii) the atypical signaling pathways of AT2R and (iii) the absence of appropriate selective ligands. Indeed, apart a few exceptions, the role of the AT2R was in fact revealed by the results of simultaneous treatment with Ang II and AT1R blockers or in AT2Rdeficient mice. The first aim of this review is to summarize current paradigms concerning the role of the AT2R in adipocyte differentiation and in metabolic disorders related to insulin resistance and type 2 diabetes. Secondly, we will highlight the potential utility of selective AT2R agonists in clarifying potential roles of the AT2R in adipocyte physiology. We summarized our findings using a selective and high affinity nonpeptide ligand of the AT2R and demonstrate that AT2R is involved in adipocyte differentiation and may improve insulin sensitivity in a model of insulin resistance, in addition to increase vasodilation and reduce inflammation in adipose tissue. Thus the recent development of orally active, selective AT2R agonists should facilitate efforts to elucidate the distinct roles of the AT2R in physiology, including adipocyte physiology.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
Angiotensin II
angiotensin type 2 receptor
angiotensin type 1 receptor
adipocyte
differentiation
insulin resistance
adipocytes
AT1R blockade
proliferator-activated receptor

Added entries (persons, corporate bodies, meetings, titles ...)

Shum, Michael (author)
Baillargeon, Jean-Patrice (author)
Langlois, Marie-France (author)
Wallinder, CharlottaUppsala universitet,Avdelningen för organisk farmaceutisk kemi(Swepub:uu)chwal103 (author)
Alterman, MathiasUppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)mathialt (author)
Hallberg, AndersUppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)andehall (author)
C. Carpentier, Andre (author)
Uppsala universitetAvdelningen för organisk farmaceutisk kemi (creator_code:org_t)

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In:current hypertension reviews: bentham science publishers8:1, s. 47-591573-4021

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