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Morphological and f...
Morphological and functional evaluation of the bioresorption of the bioresorbable everolimus-eluting vascular scaffold using IVUS, echogenicity and vasomotion testing at two year follow-up : a patient level insight into the ABSORB A clinical trial
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- Sarno, Giovanna (author)
- Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
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Bruining, Nico (author)
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Onuma, Yoshinobu (author)
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Garg, Scot (author)
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Brugaletta, Salvatore (author)
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De Winter, Sebastiaan (author)
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Regar, Evelyn (author)
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Thuesen, Leif (author)
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Dudek, Dariusz (author)
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Veldhof, Susan (author)
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Dorange, Cecile (author)
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Garcia-Garcia, Hector M (author)
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Ormiston, John A (author)
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Serruys, Patrick W (author)
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(creator_code:org_t)
- 2011-01-07
- 2012
- English.
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In: The international journal of cardiovascular imaging. - : Springer Science and Business Media LLC. - 1875-8312 .- 1569-5794 .- 1573-0743. ; 28:1, s. 51-58
- Related links:
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https://repub.eur.nl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The aim of this study was to describe vaso-reactivity (by Acetylcholine and Methergine tests) at 2 year follow-up in parallel with the individual changes in the echogenicity characteristics of the polymer struts of the everolimus eluting bioresorbable vascular scaffold (BVS), from post-treatment to 2 year follow-up, in patients enrolled in the ABSORB Cohort A study. Intravascular ultrasound assessment was performed with a phased array catheter (EagleEye, Volcano Corporation, Cordova, CA, USA) with automated pullback at 0.5 mm per second. The % ratio at 6 months and 2 years [(Scaffold Area post PCI- Lumen Area)/Scaffold Area post PCI] was calculated as a measure of scaffold shrinkage. The % change of hyperechogenicity was defined as: ([post-procedural hyperechogenicity] - [2 year follow up hyperechogenicity])/[post-procedural hyperechogenicity]) × 100. The vasomotion test with intracoronary acetylcholine (10(-6) M) or intravenous methergine (0.4 mg) was performed at 2 years. Overall nine patients received all these analyses and were enrolled in the present analysis. A 50-96% reduction in hyperechogenicity was observed between baseline and 2 years, which corresponded to a change in vasoreactivity between 2 and 22%. A vasoconstriction of the scaffolded segment was observed in the 5 patients, who underwent the methergine test, with a mean decrease in lumen diameter after methergine of 9 ± 7% (P = 0.06), while vasodilatation occurred in the 4 patients who underwent the acetylcholine test with a mean increase in lumen diameter after acetylcholine of 8 ± 5% (P = 0.125). Bioresorption of the BVS is accompanied by re-establishment of both endothelial and non-endothelial dependent vasomotion.
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- By the author/editor
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Sarno, Giovanna
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Bruining, Nico
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Onuma, Yoshinobu
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Garg, Scot
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Brugaletta, Salv ...
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De Winter, Sebas ...
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show more...
-
Regar, Evelyn
-
Thuesen, Leif
-
Dudek, Dariusz
-
Veldhof, Susan
-
Dorange, Cecile
-
Garcia-Garcia, H ...
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Ormiston, John A
-
Serruys, Patrick ...
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show less...
- Articles in the publication
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The internationa ...
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Uppsala University