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  • Nilsson, Per H.Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC;HoRB (author)

Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Elsevier BV,2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-191995
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-191995URI
  • https://doi.org/10.1016/j.biomaterials.2012.10.040DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-22802URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • K.N.E., J.D.L., B.N. and Y.T. equally contributed to this paper as a supervisor.
  • Activation of the thrombotic and complement systems is the main recognition and effector mechanisms in the multiple adverse biological responses triggered when biomaterials or therapeutic cells come into blood contact. We have created a surface which is auto-protective to human innate immunity by combining three fundamentally different strategies, all developed by us previously, which have been shown to induce substantial, but incomplete hemocompatibility when used separately. In summary, we have conjugated a factor H-binding peptide; and an ADP-degrading enzyme; using a PEG linker on both material and cellular surfaces. When exposed to human whole blood, factor H was specifically recruited to the modified surfaces and inhibited complement attack. In addition, activation of platelets and coagulation was efficiently attenuated, by degrading ADP. Thus, by inhibiting thromboinflammation using a multicomponent approach, we have created a hybrid surface with the potential to greatly reduce incompatibility reactions involving biomaterials and transplantation.

Subject headings and genre

  • NATURVETENSKAP Biologi hsv//swe
  • NATURAL SCIENCES Biological Sciences hsv//eng
  • Apyrase
  • Coagulation
  • Complement
  • Factor H-binding peptide
  • Poly(ethylene glycol) (PEG)
  • Surface modification
  • Autoregulations
  • Biological response
  • Biomaterial surfaces
  • Blood contact
  • Complement systems
  • H-binding
  • Hemocompatibility
  • Hybrid surface
  • Innate immunity
  • Modified surfaces
  • Multicomponents
  • Whole blood
  • Biological materials
  • Biomaterials
  • Peptides
  • Polyethylene glycols
  • Surface treatment
  • Surfaces
  • 5C6 peptide
  • biomaterial
  • complement factor H
  • macrogol
  • peptide
  • unclassified drug
  • article
  • autoregulation
  • biotinylation
  • endothelium cell
  • erythrocyte
  • human
  • inflammation
  • multicomponent therapeutic coating
  • peptide synthesis
  • porcine aortic endothelial cell
  • priority journal
  • protein immobilization
  • thromboinflammation
  • Biomedical Sciences

Added entries (persons, corporate bodies, meetings, titles ...)

  • N. Ekdahl, KristinaLinnéuniversitetet,Uppsala universitet,Klinisk immunologi,Institutionen för kemi och biomedicin (KOB),Uppsala University,Linnaeus Ctr Biomat Chem, BMC(Swepub:lnu)nnikr (author)
  • Magnusson, Peetra U.Uppsala universitet,Klinisk immunologi,Uppsala University(Swepub:uu)petrmagn (author)
  • Qu, HongchangUniversity of Pennsylvania, USA (author)
  • Iwata, HirooKyoto University, Japan (author)
  • Ricklin, DanielUniversity of Pennsylvania, USA (author)
  • Hong, JaanUppsala universitet,Klinisk immunologi,Uppsala University(Swepub:uu)jaanhong (author)
  • Lambris, John D.University of Pennsylvania, USA (author)
  • Nilsson, BoUppsala universitet,Klinisk immunologi,Uppsala University(Swepub:uu)bonils (author)
  • Teramura, YujiUppsala universitet,Klinisk immunologi,Uppsala University;Kyoto University, Japan(Swepub:uu)yujte186 (author)
  • LinnéuniversitetetInstitutionen för kemi och biomedicin (KOB) (creator_code:org_t)

Related titles

  • In:Biomaterials: Elsevier BV34:4, s. 985-9940142-96121878-5905

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