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The prognostic role...
The prognostic role of TGF-β signaling pathway in breast cancer patients
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- de Kruijf, E M (author)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
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- Dekker, T J A (author)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
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- Hawinkels, L J A C (author)
- Departments of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
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- Putter, H (author)
- Departments of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
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- Smit, V T H B M (author)
- Departments of Pathology, Leiden University Medical Center, Leiden, The Netherlands
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- Kroep, J R (author)
- Departments of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands
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- Kuppen, P J K (author)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
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- van de Velde, C J H (author)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
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- ten Dijke, Peter (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Tollenaar, R A E M (author)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
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- Mesker, W E (author)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 24:2, s. 384-390
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Abstract
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- BackgroundThe transforming growth factor-β (TGF-β) pathway has dual effects on tumor growth. Seemingly, discordant results have been published on the relation between TGF-β signaling markers and prognosis in breast cancer. Improved prognostic information for breast cancer patients might be obtained by assessing interactions among TGF-β signaling biomarkers.Patients and methodsThe expression of nuclear Smad4, nuclear phosphorylated-Smad2 (p-Smad2), and the membranous expression of TGF-β receptors I and II (TβRI and TβRII) was determined on a tissue microarray of 574 breast carcinomas. Tumors were stratified according to the Smad4 expression in combination with p-Smad2 expression or Smad4 in combination with the expression of both TGF-β receptors.ResultsTumors with high expression of TβRII, TβRI and TβRII, and p-Smad2 (P = 0.018, 0.005, and 0.022, respectively), and low expression of Smad4 (P = 0.005) had an unfavorable prognosis concerning progression-free survival. Low Smad4 expression combined with high p-Smad2 expression or low expression of Smad4 combined with high expression of both TGF-β receptors displayed an increased hazard ratio of 3.04 [95% confidence interval (CI) 1.390-6.658] and 2.20 (95% CI 1.464-3.307), respectively, for disease relapse.ConclusionsCombining TGF-β biomarkers provides prognostic information for patients with stage I-III breast cancer. This can identify patients at increased risk for disease recurrence that might therefore be candidates for additional treatment.
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- By the author/editor
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de Kruijf, E M
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Dekker, T J A
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Hawinkels, L J A ...
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Putter, H
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Smit, V T H B M
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Kroep, J R
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show more...
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Kuppen, P J K
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van de Velde, C ...
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ten Dijke, Peter
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Tollenaar, R A E ...
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Mesker, W E
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show less...
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Annals of Oncolo ...
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Uppsala University