Search: onr:"swepub:oai:DiVA.org:uu-194828" >
Meta-Analysis Inves...
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Nettleton, Jennifer A.
(author)
Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-12-19
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Oxford University Press (OUP),2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-194828
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194828URI
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https://doi.org/10.1093/aje/kws297DOI
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https://lup.lub.lu.se/record/3470537URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125973634URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66407URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 US and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and FI levels and 2) interactions of diet score with 16 FG-associated loci and 2 FI-associated loci. Diet score (per unit increase) was inversely associated with FG ( 0.004 mmol/L, 95 confidence interval: 0.005, 0.003) and FI ( 0.008 ln-pmol/L, 95 confidence interval: 0.009, 0.007) levels after adjustment for demographic factors, lifestyle, and body mass index. Genotype variation at the studied loci did not modify these associations. Healthier diets were associated with lower FG and FI concentrations regardless of genotype at previously replicated FG- and FI-associated loci. Studies focusing on genomic regions that do not yield highly statistically significant associations from main-effect genome-wide association studies may be more fruitful in identifying diet-gene interactions.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Hivert, Marie-France
(author)
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Lemaitre, Rozenn N.
(author)
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McKeown, Nicola M.
(author)
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Mozaffarian, Dariush
(author)
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Tanaka, Toshiko
(author)
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Wojczynski, Mary K.
(author)
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Hruby, Adela
(author)
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Djousse, Luc
(author)
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Ngwa, Julius S.
(author)
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Follis, Jack L.
(author)
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Dimitriou, Maria
(author)
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Ganna, AndreaKarolinska Institutet
(author)
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Houston, Denise K.
(author)
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Kanoni, Stavroula
(author)
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Mikkila, Vera
(author)
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Manichaikul, Ani
(author)
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Ntalla, Ioanna
(author)
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Renström, FridaUmeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin(Swepub:umu)frre0001
(author)
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Sonestedt, EmilyLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Nutritionsepidemiologi,Diabetes - Cardiovascular Disease,Lund University Research Groups,Nutrition Epidemiology(Swepub:lu)medf-eso
(author)
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van Rooij, Frank J. A.
(author)
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Bandinelli, Stefania
(author)
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de Koning, Lawrence
(author)
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Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Nutritionsepidemiologi,Diabetes - Cardiovascular Disease,Lund University Research Groups,Nutrition Epidemiology(Swepub:lu)medf-upe
(author)
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Hassanali, Neelam
(author)
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Kiefte-de Jong, Jessica C.
(author)
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Lohman, Kurt K.
(author)
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Raitakari, Olli
(author)
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Papoutsakis, Constantina
(author)
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Sjögren, PerUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)persj732
(author)
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Stirrups, Kathleen
(author)
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Ax, ErikaUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)eriax774
(author)
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Deloukas, Panos
(author)
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Groves, Christopher J.
(author)
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Franks, PaulUmeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin(Swepub:umu)pafr0003
(author)
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Johansson, IngegerdUmeå universitet,Kariologi(Swepub:umu)injo0003
(author)
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Liu, Yongmei
(author)
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McCarthy, Mark I.
(author)
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North, Kari
(author)
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Viikari, Jorma
(author)
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Zillikens, M. Carola
(author)
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Dupuis, Josee
(author)
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Hofman, Albert
(author)
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Kolovou, Genovefa
(author)
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Mukamal, Kenneth
(author)
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Prokopenko, Inga
(author)
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Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005
(author)
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Seppala, Ilkka
(author)
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Cupples, L. Adrienne
(author)
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Hu, Frank B.
(author)
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Kahonen, Mika
(author)
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Uitterlinden, Andre G.
(author)
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Borecki, Ingrid B.
(author)
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Ferrucci, Luigi
(author)
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Jacobs, David R., Jr.
(author)
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Kritchevsky, Stephen B.
(author)
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Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor
(author)
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Pankow, James S.
(author)
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Lehtimaki, Terho
(author)
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Witteman, Jacqueline C. M.
(author)
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Ingelsson, Erik
(author)
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Siscovick, David S.
(author)
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Dedoussis, George
(author)
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Meigs, James B.
(author)
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Franks, Paul W.
(author)
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Karolinska InstitutetGenetisk och molekylär epidemiologi
(creator_code:org_t)
Related titles
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In:American Journal of Epidemiology: Oxford University Press (OUP)177:2, s. 103-1150002-92621476-6256
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Nettleton, Jenni ...
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Hivert, Marie-Fr ...
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Lemaitre, Rozenn ...
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McKeown, Nicola ...
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Mozaffarian, Dar ...
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Tanaka, Toshiko
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show more...
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Wojczynski, Mary ...
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Hruby, Adela
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Djousse, Luc
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Ngwa, Julius S.
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Follis, Jack L.
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Dimitriou, Maria
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Ganna, Andrea
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Houston, Denise ...
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Kanoni, Stavroul ...
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Mikkila, Vera
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Manichaikul, Ani
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Ntalla, Ioanna
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Renström, Frida
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Sonestedt, Emily
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van Rooij, Frank ...
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Bandinelli, Stef ...
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de Koning, Lawre ...
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Ericson, Ulrika
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Hassanali, Neela ...
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Kiefte-de Jong, ...
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Lohman, Kurt K.
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Raitakari, Olli
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Papoutsakis, Con ...
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Sjögren, Per
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Stirrups, Kathle ...
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Ax, Erika
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Deloukas, Panos
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Groves, Christop ...
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Franks, Paul
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Johansson, Ingeg ...
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Liu, Yongmei
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McCarthy, Mark I ...
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North, Kari
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Viikari, Jorma
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Zillikens, M. Ca ...
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Dupuis, Josee
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Hofman, Albert
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Kolovou, Genovef ...
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Mukamal, Kenneth
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Prokopenko, Inga
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Rolandsson, Olov
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Seppala, Ilkka
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Cupples, L. Adri ...
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Hu, Frank B.
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Kahonen, Mika
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Uitterlinden, An ...
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Borecki, Ingrid ...
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Ferrucci, Luigi
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Jacobs, David R. ...
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Kritchevsky, Ste ...
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Orho-Melander, M ...
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Pankow, James S.
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Lehtimaki, Terho
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Witteman, Jacque ...
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Ingelsson, Erik
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Siscovick, David ...
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Dedoussis, Georg ...
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Meigs, James B.
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Franks, Paul W.
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Uppsala University
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Lund University
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Karolinska Institutet
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Umeå University