Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions

• Two straightforward and convenient routes for the synthesis of the antimalarial agents FR900098 and fosmidomycin are described. In the key steps N- or P-alkylation reactions are used. The best overall yields of FR900098 and fosmidomycin in 15 mmol scale are 83% and 68%, respectively. These routes utilize readily available materials and avoid harsh conditions.

Keyword

Fosmidomycin

FR900098

N-alkylation

P-alkylation

3 (n acetyl n hydroxyamino)propylphosphonic acid

antimalarial agent

nitrogen

phosphorus

unclassified drug

alkylation

article

drug synthesis

priority journal

Publication and Content Type

ref (subject category)

art (subject category)