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Triazolopyrimidinones as gamma-secretase modulators : structure-activity relationship, modulator profile, and in vivo profiling
- Yngve, Ulrika (author)
- Paulsen, Kim (author)
- Macsari, Istvan (author)
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- Sundstrom, Marie (author)
- Santangelo, Ellen (author)
- Linde, Christian (author)
- Bogar, Krisztian (author)
- Lake, Fredrik (author)
- Besidski, Yevgeni (author)
- Malmborg, Jonas (author)
- Stromberg, Kia (author)
- Appelkvist, Paulina (author)
- Radesater, Ann-Cathrine (author)
- Olsson, Fredrik (author)
- Bergstrom, Daniel (author)
- Klintenberg, Rebecka (author)
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- (creator_code:org_t)
- Royal Society of Chemistry (RSC), 2013
- 2013
- English.
- In: MedChemComm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 4:2, s. 422-431
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The structure-activity relationship for a series of potent g-secretase modulators based on the 6,7-dihydro4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one scaffold is described. Furthermore, we report details regarding the modulator profile on A beta processing, as well as in vivo efficacy, for the optimized compounds.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
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- Yngve, Ulrika
- Paulsen, Kim
- Macsari, Istvan
- Sundstrom, Marie
- Santangelo, Elle ...
- Linde, Christian
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- Bogar, Krisztian
- Lake, Fredrik
- Besidski, Yevgen ...
- Malmborg, Jonas
- Stromberg, Kia
- Appelkvist, Paul ...
- Radesater, Ann-C ...
- Olsson, Fredrik
- Bergstrom, Danie ...
- Klintenberg, Reb ...
- Arvidsson, Per I ...
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- MedChemComm
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- Uppsala University
- Karolinska Institutet
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