Individual Common Carotid Artery Wall Layer Dimensions, but Not Carotid Intima-Media Thickness, Indicate Increased Cardiovascular Risk in Women With Preeclampsia: An investigation using non-invasive high-frequency ultrasound

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Akhter, Tansim,1967-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Gynekologisk endokrinologi/Naessén (author)

Individual Common Carotid Artery Wall Layer Dimensions, but Not Carotid Intima-Media Thickness, Indicate Increased Cardiovascular Risk in Women With Preeclampsia : An investigation using non-invasive high-frequency ultrasound

Article/chapterEnglish2013

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2013
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LIBRIS-ID:oai:DiVA.org:uu-197189
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197189URI
https://doi.org/10.1161/CIRCIMAGING.113.000295DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127537239URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Background Preeclampsia (PE) is associated with increased risk of cardiovascular disease later in life. Ultrasound assessment of the common carotid artery intima-media thickness (IMT) during or after PE has not indicated any increased cardiovascular risk. Methods and Results We used high-frequency ultrasound (22 MHz) to estimate the individual common carotid artery IMTs in 55 women at PE diagnosis and in 64 women with normal pregnancies at a similar stage. All were re-examined about 1 year postpartum. A thick intima, thin media, and high intima/media (I/M) ratio are signs of a less healthy artery wall. PE was associated with a significantly thicker mean common carotid artery intima, thinner media, and higher I/M ratio than in normal pregnancy (mean I/M difference, 0.21; 95% confidence interval, 0.17-0.25; P<0.0001). After adjustment for first trimester body mass index and mean arterial pressure, differences in intima thickness and I/M remained significant. About 1 year postpartum, these values had improved in both groups, but group differences remained significant (all adjusted P<0.0001). There were no significant differences in IMT between groups. In receiver-operating characteristic curve analysis, intima thickness and I/M were strongly predictive of prevalent PE (area under the curve, approximate to 0.95), whereas IMT was not (area under the curve, 0.49). Conclusions The arteries of women with PE were negatively affected during pregnancy and 1 year postpartum compared with women with normal pregnancies, indicating increased cardiovascular risk. Estimation of intima thickness and I/M ratio seem preferable to estimation of common carotid artery IMT in imaging cardiovascular risk in PE. Results from this pilot study warrant further confirmation.

Subject headings and genre

Preeclampsia
cardiovascular disease
common carotid artery
high-frequency ultrasound
intima/media ratio.

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Wikström, Anna-Karin,1965-Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Högberg(Swepub:uu)annwi179 (author)
Larsson, MaritaUppsala universitet,Institutionen för kvinnors och barns hälsa,Gynekologisk endokrinologi/Naessén (author)
Naessén, TordUppsala universitet,Institutionen för kvinnors och barns hälsa,Gynekologisk endokrinologi/Naessén(Swepub:uu)tordnaes (author)
Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

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In:Circulation Cardiovascular Imaging6:5, s. 762-7681941-96511942-0080

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