SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-19740"
 

Search: onr:"swepub:oai:DiVA.org:uu-19740" > Highly Active Antir...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Kappert, Kai (author)

Highly Active Antiretroviral Therapy Attenuates Re-Endothelialization and Alters Neointima Formation in the Rat Carotid Artery After Balloon Injury

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2006
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-19740
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-19740URI
  • https://doi.org/10.1097/01.qai.0000232610.93867.2fDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1943253URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Highly active antiretroviral therapy (HAART) has led to a sustained decline of HIV-associated morbidity and mortality. HAART exhibits significant side effects, however, such as hyperlipidemia and hyperglycemia, which possibly contribute to accelerated atherosclerosis in HAART-treated patients. In addition, direct effects of HAART on vascular cells have been described, which may promote atherosclerotic lesion formation. The effects of HAART on balloon-induced neointima formation have not been studied previously. The rat carotid artery balloon model was used to evaluate the effects of HAART (lopinavir, ritonavir, lamivudine, and zidovudine) on neointima formation and endothelial recovery. Furthermore, the effects of concomitant administration of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor rosuvastatin were investigated. HAART-treated animals displayed an increase in lesion size (neointima/media ratio: 1.14 +/- 0.32 vs. 1.31 +/- 0.20 in control vs. HAART; P < 0.05) and an impaired regenerative capacity of the endothelium, as indicated by reduction in endothelial regrowth from an adjacent undilated vessel segment 14 days after injury (re-endothelialization area: 8.29 +/- 1.45 mm vs. 5.09 +/- 0.53 mm in control vs. HAART; P < 0.05). When rosuvastatin was given in addition to HAART, these effects were not observed. In conclusion, HAART inhibited endothelial cell-mediated healing and promoted neointima formation after angioplasty in rats. These deleterious effects were attenuated by cotreatment with rosuvastatin, however. Our studies suggest that currently used drug regimens against HIV infection may lead to an increased risk for restenosis after percutaneous vascular interventions. Moreover, the findings indicate that the additional treatment with statins might counteract these adverse effects by HAART.

Subject headings and genre

  • AIDS
  • atherosclerosis
  • highly active antiretroviral therapy
  • neointima formation
  • restenosis
  • vascular smooth muscle cell
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Leppänen, OlliUppsala universitet,Kärlkirurgi (author)
  • Paulsson, JannaKarolinska Institutet (author)
  • Furuhashi, MasaoUppsala universitet,Ludwiginstitutet för cancerforskning (author)
  • Carlsson, Mari-AnneUppsala universitet,Kärlkirurgi(Swepub:uu)macarls (author)
  • Heldin, Carl-HenrikUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)carlheld (author)
  • Fätkenheuer, Gerd (author)
  • Rosenkranz, Stephan (author)
  • Östman, ArneKarolinska Institutet (author)
  • Uppsala universitetKärlkirurgi (creator_code:org_t)

Related titles

  • In:Journal of Acquired Immune Deficiency Syndromes: Ovid Technologies (Wolters Kluwer Health)43:4, s. 383-3921525-41351944-7884

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view