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General mechanisms ...
General mechanisms of coagulation and targets of anticoagulants (Section I) : Position Paper of the ESC Working Group on Thrombosis - Task Force on Anticoagulants in Heart Disease
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De Caterina, R (author)
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Husted, S (author)
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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Andreotti, F (author)
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Arnesen, H (author)
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Bachmann, F (author)
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Baigent, C (author)
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Huber, K (author)
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Jespersen, J (author)
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Kristensen, S D (author)
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Lip, G Y H (author)
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Morais, J (author)
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Rasmussen, L H (author)
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- Siegbahn, Agneta (author)
- Uppsala universitet,Koagulation och inflammationsvetenskap
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Verheugt, F W A (author)
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Weitz, J I (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Thrombosis and Haemostasis. - 0340-6245 .- 2567-689X. ; 109:4, s. 569-579
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Contrary to previous models based on plasma, coagulation processes are currently believed to be mostly cell surface-based, including three overlapping phases: initiation, when tissue factor-expressing cells and microparticles are exposed to plasma; amplification, whereby small amounts of thrombin induce platelet activation and aggregation, and promote activation of factors (F)V, FVIII and FXI on platelet surfaces; and propagation, in which the Xase (tenase) and prothrombinase complexes are formed, producing a burst of thrombin and the cleavage of fibrinogen to fibrin. Thrombin exerts a number of additional biological actions, including platelet activation, amplification and self-inhibition of coagulation, clot stabilisation and anti-fibrinolysis, in processes occurring in the proximity of vessel injury, tightly regulated by a series of inhibitory mechanisms. "Classical" anticoagulants, including heparin and vitamin K antagonists, typically target multiple coagulation steps. A number of new anticoagulants, already developed or under development, target specific steps in the process, inhibiting a single coagulation factor or mimicking natural coagulation inhibitors.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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De Caterina, R
-
Husted, S
-
Wallentin, Lars
-
Andreotti, F
-
Arnesen, H
-
Bachmann, F
-
show more...
-
Baigent, C
-
Huber, K
-
Jespersen, J
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Kristensen, S D
-
Lip, G Y H
-
Morais, J
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Rasmussen, L H
-
Siegbahn, Agneta
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Verheugt, F W A
-
Weitz, J I
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show less...
- Articles in the publication
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Thrombosis and H ...
- By the university
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Uppsala University