Search: onr:"swepub:oai:DiVA.org:uu-197725" >
Combination therapy...
Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris : a multicentre, randomized, double-blind controlled study
-
Dréno, B (author)
-
Kaufmann, R (author)
-
Talarico, S (author)
-
show more...
-
Torres Lozada, V (author)
-
Rodríguez-Castellanos, M A (author)
-
Gómez-Flores, M (author)
-
De Maubeuge, J (author)
-
- Berg, M (author)
- Department of Dermatology Sörmland, Mälar Hospital, Eskilstuna, Sweden
-
Foley, P (author)
-
Sysa-Jedrzejowska, A (author)
-
Kerrouche, N (author)
-
Paliargues, F (author)
-
Bettoli, V (author)
-
show less...
-
(creator_code:org_t)
- 2011-07-06
- 2011
- English.
-
In: British Journal of Dermatology. - : Oxford University Press (OUP). - 0007-0963 .- 1365-2133. ; 165:2, s. 383-390
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND:Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris.OBJECTIVES:To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0·1%-BPO 2·5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris.METHODS:A total of 378 subjects were randomized in a double-blind, controlled trial to receive once-daily lymecycline with either A/BPO or vehicle for 12 weeks. Evaluations included percentage changes from baseline in lesion counts, success rate (subjects 'clear' or 'almost clear'), skin tolerability, adverse events and patients' satisfaction.RESULTS:The median percentage reduction from baseline in total lesion counts at week 12 was significantly higher (P < 0·001) in the lymecycline with A/BPO group (-74·1%) than in the lymecycline with vehicle group (-56·8%). The success rate was significantly higher (47·6% vs. 33·7%, P = 0·002) in subjects treated with lymecycline and A/BPO. Both inflammatory and noninflammatory lesions were significantly reduced at week 12 (both P < 0·001) with a rapid onset of action from week 2 for noninflammatory lesions (P < 0·001) and week 4 for inflammatory lesions (P = 0·005). The A/BPO and lymecycline combination was well tolerated. The proportion of satisfied and very satisfied subjects was similar in both groups, but the number in the A/BPO group who were 'very satisfied' was significantly greater (P = 0·031).CONCLUSION:These results demonstrate the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Dréno, B
-
Kaufmann, R
-
Talarico, S
-
Torres Lozada, V
-
Rodríguez-Castel ...
-
Gómez-Flores, M
-
show more...
-
De Maubeuge, J
-
Berg, M
-
Foley, P
-
Sysa-Jedrzejowsk ...
-
Kerrouche, N
-
Paliargues, F
-
Bettoli, V
-
show less...
- Articles in the publication
-
British Journal ...
- By the university
-
Uppsala University