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Morphology of coron...
Morphology of coronary artery lesions assessed by virtual histology intravascular ultrasound tissue characterization and fractional flow reserve
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Brugaletta, Salvatore (author)
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Garcia-Garcia, Hector M (author)
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Shen, Zhu Jun (author)
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Gomez-Lara, Josep (author)
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Diletti, Roberto (author)
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- Sarno, Giovanna (author)
- Z120, Thoraxcentre, Erasmus MC, CE Rotterdam, The Netherlands
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Gonzalo, Nieves (author)
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Wijns, William (author)
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de Bruyne, Bernard (author)
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Alfonso, Fernando (author)
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Serruys, Patrick W (author)
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(creator_code:org_t)
- 2011-02-19
- 2012
- English.
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In: The International Journal of Cardiovascular Imaging. - : Springer Science and Business Media LLC. - 1569-5794 .- 1875-8312 .- 1573-0743. ; 28:2, s. 221-228
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https://repub.eur.nl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Fractional flow reserve (FFR) is an index of the physiological significance of a coronary stenosis. Patients who have lesions with a FFR of >0.80, even optimally treated with medication, have however a MACE rate ranging from 8 to 21%. Coronary plaques at high risk of rupture and clinical events can be also identified by virtual histology intravascular ultrasound (IVUS-VH) as plaques with high amount of necrotic core (NC) abutting the lumen. Aim of this exploratory study was to investigate whether the geometry and composition of lesions with FFR ≤ 0.80 were different from their counterparts. Fifty-five consecutive patients in whom FFR was clinically indicated on a moderate angiographic lesion, received also an imaging investigation on the same lesion with IVUS-VH. Data on plaque geometry and composition was analyzed. Patients were subdivided in two groups according to the value of FFR (> or ≤0.80). Lesions with a FFR ≤ 0.80 (n = 17) showed a slightly larger plaque burden than those with FFR > 0.80 (n = 38) (54.6 ± 0.7% vs. 51.7 ± 0.7% P = 0.1). In addition, they tend to have less content of necrotic core than their counterparts (14.2 ± 8% vs. 19.2 ± 10.2%, P = 0.08). No difference was found in the distribution of NC-rich plaques (fibroatheroma and thin-capped fibroatheroma) between groups (82% in FFR ≤ 0.80 vs. 79% in FFR > 0.80, P = 0.5). Although FFR ≤ 0.80 lesions have larger plaque size, they do not differ in composition from the ones with FFR > 0.80. Further exploration in a large prospective study is needed to study whether the lesions with FFR > 0.80 that are NC rich are the ones associated with the presence of clinical events at follow-up.
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Brugaletta, Salv ...
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Garcia-Garcia, H ...
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Shen, Zhu Jun
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Gomez-Lara, Jose ...
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Diletti, Roberto
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Sarno, Giovanna
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show more...
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Gonzalo, Nieves
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Wijns, William
-
de Bruyne, Berna ...
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Alfonso, Fernand ...
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Serruys, Patrick ...
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show less...
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The Internationa ...
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Uppsala University