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  • Brugaletta, Salvatore (author)

Morphology of coronary artery lesions assessed by virtual histology intravascular ultrasound tissue characterization and fractional flow reserve

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2011-02-19
  • Springer Science and Business Media LLC,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-198195
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198195URI
  • https://doi.org/10.1007/s10554-011-9816-3DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Fractional flow reserve (FFR) is an index of the physiological significance of a coronary stenosis. Patients who have lesions with a FFR of >0.80, even optimally treated with medication, have however a MACE rate ranging from 8 to 21%. Coronary plaques at high risk of rupture and clinical events can be also identified by virtual histology intravascular ultrasound (IVUS-VH) as plaques with high amount of necrotic core (NC) abutting the lumen. Aim of this exploratory study was to investigate whether the geometry and composition of lesions with FFR ≤ 0.80 were different from their counterparts. Fifty-five consecutive patients in whom FFR was clinically indicated on a moderate angiographic lesion, received also an imaging investigation on the same lesion with IVUS-VH. Data on plaque geometry and composition was analyzed. Patients were subdivided in two groups according to the value of FFR (> or ≤0.80). Lesions with a FFR ≤ 0.80 (n = 17) showed a slightly larger plaque burden than those with FFR > 0.80 (n = 38) (54.6 ± 0.7% vs. 51.7 ± 0.7% P = 0.1). In addition, they tend to have less content of necrotic core than their counterparts (14.2 ± 8% vs. 19.2 ± 10.2%, P = 0.08). No difference was found in the distribution of NC-rich plaques (fibroatheroma and thin-capped fibroatheroma) between groups (82% in FFR ≤ 0.80 vs. 79% in FFR > 0.80, P = 0.5). Although FFR ≤ 0.80 lesions have larger plaque size, they do not differ in composition from the ones with FFR > 0.80. Further exploration in a large prospective study is needed to study whether the lesions with FFR > 0.80 that are NC rich are the ones associated with the presence of clinical events at follow-up.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Garcia-Garcia, Hector M (author)
  • Shen, Zhu Jun (author)
  • Gomez-Lara, Josep (author)
  • Diletti, Roberto (author)
  • Sarno, GiovannaZ120, Thoraxcentre, Erasmus MC, CE Rotterdam, The Netherlands(Swepub:uu)giosa853 (author)
  • Gonzalo, Nieves (author)
  • Wijns, William (author)
  • de Bruyne, Bernard (author)
  • Alfonso, Fernando (author)
  • Serruys, Patrick W (author)
  • Z120, Thoraxcentre, Erasmus MC, CE Rotterdam, The Netherlands (creator_code:org_t)

Related titles

  • In:The International Journal of Cardiovascular Imaging: Springer Science and Business Media LLC28:2, s. 221-2281569-57941875-83121573-0743

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