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The frequency of an...
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Thompson, Simon R.
(author)
The frequency of an IL-18-associated haplotype in Africans
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-08-29
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Springer Science and Business Media LLC,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-199715
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199715URI
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https://doi.org/10.1038/ejhg.2012.184DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Variation within the gene for the proinflammatory cytokine interleukin (IL)-18 has been associated with inter-individual differences in levels of free protein and disease risk. We investigated the frequency of function-associated IL18 gene haplotypes in an extensive sample (n=2357) of African populations from across the continent. A previously identified five tagging SNP (single-nucleotide polymorphism) haplotype (here designated hGTATA), known to be associated with lower levels of IL-18, was observed at a frequency of 27% in a British population of recent European ancestry, but was found at low frequency (<8%) or completely absent in African populations. Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk.
Subject headings and genre
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IL-18
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atherosclerosis
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genetic diversity
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Africa
Added entries (persons, corporate bodies, meetings, titles ...)
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Humphries, Steve E.
(author)
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Thomas, Mark G.Uppsala universitet,Evolutionsbiologi(Swepub:uu)marth133
(author)
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Ekong, Rosemary
(author)
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Tarekegn, Ayele
(author)
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Bekele, Endeshaw
(author)
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Creemer, Olivia
(author)
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Bradman, Neil
(author)
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Veeramah, Krishna R.
(author)
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Uppsala universitetEvolutionsbiologi
(creator_code:org_t)
Related titles
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In:European Journal of Human Genetics: Springer Science and Business Media LLC21:4, s. 465-4681018-48131476-5438
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