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Low expression of m...
Low expression of microRNA-129-5p predicts poor clinical outcome in diffuse large B cell lymphoma (DLBCL)
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- Hedström, Gustav (author)
- Uppsala universitet,Enheten för onkologi
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- Thunberg, Ulf (author)
- Uppsala universitet,Enheten för onkologi
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- Berglund, Mattias (author)
- Uppsala universitet,Enheten för onkologi
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- Simonsson, Martin (author)
- Uppsala universitet,Enheten för onkologi
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- Amini, Rose-Marie (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Enblad, Gunilla (author)
- Uppsala universitet,Enheten för onkologi
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(creator_code:org_t)
- 2013-03-05
- 2013
- English.
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In: International Journal of Hematology. - : Springer Science and Business Media LLC. - 0925-5710 .- 1865-3774. ; 97:4, s. 465-471
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Diffuse large B cell lymphoma (DLBCL) is a heterogeneous group of B cell lymphomas. MicroRNA expression provides a new and interesting tool for understanding the biology and clinical course of DLBCL. The present study presents microRNA-129-5p expression data from DLBCL patients treated with CHOP or R-CHOP. Patients with low microRNA-129-5p expression had a median survival of 23 months and a significantly shorter overall survival (P = 0.0042) compared to patients with high microRNA-129-5p expression, who had a median survival of 58 months. We also found that patients treated with R-CHOP only and displaying low microRNA-129-5p expression had a significantly shorter overall survival compared to patients with high microRNA-129-5p expression; all such patients were still alive at the time of last follow-up (P = 0.043). No significant difference was found among microRNA-129-5p expression in tumor tissue, the tissue surrounding the tumor, and normal controls. To our knowledge, this is the first report to show that the expression of microRNA-129-5p can affect the clinical outcome of DLBCL patients and that microRNA-129-5p may be involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-129-5p in DLBCL.
Keyword
- DLBCL
- microRNA-129-5p
- Prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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