Sökning: onr:"swepub:oai:DiVA.org:uu-201779" >
Manganese-induced p...
Manganese-induced parkinsonism in methcathinone abusers : bio-markers of exposure and follow-up
-
Sikk, K. (författare)
-
Haldre, S. (författare)
-
- Aquilonius, Sten-Magnus (författare)
- Uppsala universitet,Neurologi
-
visa fler...
-
Asser, A. (författare)
-
Paris, M. (författare)
-
Roose, A. (författare)
-
- Pettersson, Jean (författare)
- Uppsala universitet,Analytisk kemi
-
- Eriksson, S. -L (författare)
- Uppsala universitet,Analytisk kemi
-
- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi
-
Taba, P. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2013-01-24
- 2013
- Engelska.
-
Ingår i: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 20:6, s. 915-920
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background and purpose Methcathinone abuse is a new cause of manganism. The psychostimulant is prepared from pseudoephedrine using potassium permanganate as an oxidant. We describe the clinical, biological, neuroimaging characteristics and follow-up results in a large Estonian cohort of intravenous methcathinone users. Methods During 20062012 we studied 38 methcathinone abusers with a mean age of 33years. Subjects were rated by the Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr (HY), and Schwab and England (SE) rating scales. Twenty-four cases were reassessed 970 (20 +/- 15)months after the initial evaluation. Manganese (Mn) in plasma and hair was analysed by inductively coupled plasma-atom emission spectrometry. Magnetic resonance imaging (MRI) was performed in 11, and single-photon emission computed tomography (SPECT) with iodobenzamide (IBZM) in eight subjects. Results The average total UPDRS score was 43 +/- 21. The most severely affected domains in UPDRS Part III were speech and postural stability, the least affected domain was resting tremor. At follow-up there was worsening of HY and SE rating scales. Subjects had a higher mean level of Mn in hair (2.9 +/- 3.8ppm) than controls (0.82 +/- 1.02ppm), P=0.02. Plasma Mn concentrations were higher (11.5 +/- 6.2ppb) in active than in former users (5.6 +/- 1.8ppb), P=0.006. Active methcathinone users had increased MRI T1-signal intensity in the globus pallidus, substantia nigra and periaquaductal gray matter. IBZM-SPECT showed normal symmetric tracer uptake in striatum. Conclusion Methcathinone abusers develop a distinctive hypokinetic syndrome. Though the biomarkers of Mn exposure are characteristic only of recent abuse, the syndrome is not reversible.
Nyckelord
- ephedrone
- follow-up
- manganism
- methcathinone
- MRI hyperintensities
- parkinsonism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Sikk, K.
-
Haldre, S.
-
Aquilonius, Sten ...
-
Asser, A.
-
Paris, M.
-
Roose, A.
-
visa fler...
-
Pettersson, Jean
-
Eriksson, S. -L
-
Bergquist, Jonas
-
Taba, P.
-
visa färre...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Uppsala universitet