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Dynamics of Hippoca...
Dynamics of Hippocampal Neurogenesis in Adult Humans
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- Spaulding, Kirsty (author)
- Karolinska Institutet
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- Bergmann, Olaf (author)
- Karolinska Institutet
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- Alkass, Kanar (author)
- Karolinska Institutet
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Bernard, Samuel (author)
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- Salehpour, Mehran, 1960- (author)
- Uppsala universitet,Tandemlaboratoriet,Jonfysik
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- Huttner, Hagen (author)
- Karolinska Institutet
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Boström, Emil (author)
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- Westerlund, Isabelle (author)
- Karolinska Institutet
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Vial, Céline (author)
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Buchholz, Bruce (author)
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- Possnert, Göran (author)
- Uppsala universitet,Tillämpad kärnfysik
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Mash, Deborah (author)
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Druid, Henrik (author)
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- Frisén, Jonas (author)
- Karolinska Institutet
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(creator_code:org_t)
- Maryland Heights, MO, USA : Elsevier, 2013
- 2013
- English.
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In: Cell. - Maryland Heights, MO, USA : Elsevier. - 0092-8674 .- 1097-4172. ; 153:6, s. 1219-1227
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https://uu.diva-port... (primary) (Raw object)
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http://www.cell.com/...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have func- tional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear- bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dy- namics. We found that a large subpopulation of hip- pocampal neurons constituting one-third of the neu- rons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neu- rons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neuro- genesis may contribute to human brain function.
Subject headings
- NATURVETENSKAP -- Fysik -- Acceleratorfysik och instrumentering (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Accelerator Physics and Instrumentation (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Hippocampas
- Neurogenesis
- regeneration
- cell
- Humans
- Fysik med inriktning mot biofysik
- Physics with specialization in Biophysics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cell
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To the university's database
- By the author/editor
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Spaulding, Kirst ...
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Bergmann, Olaf
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Alkass, Kanar
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Bernard, Samuel
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Salehpour, Mehra ...
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Huttner, Hagen
-
show more...
-
Boström, Emil
-
Westerlund, Isab ...
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Vial, Céline
-
Buchholz, Bruce
-
Possnert, Göran
-
Mash, Deborah
-
Druid, Henrik
-
Frisén, Jonas
-
show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Accelerator Phys ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell
- By the university
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Uppsala University
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Karolinska Institutet