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Serum Folate and B1...
Serum Folate and B12 Levels in Association With Cognitive Impairment Among Seniors : Results From the VELESTINO Study in Greece and Meta-Analysis
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Michelakos, Theodoros (author)
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Kousoulis, Antonis A. (author)
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Katsiardanis, Konstantinos (author)
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Dessypris, Nick (author)
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Anastasiou, Anastasia (author)
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Katsiardani, Kalliopi-Penelopi (author)
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Kanavidis, Prodromos (author)
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Stefanadis, Christodoulos (author)
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- Papadopoulos, Fotios C. (author)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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Petridou, Eleni Th (author)
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(creator_code:org_t)
- 2013-04-07
- 2013
- English.
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In: Journal of Aging and Health. - : SAGE Publications. - 0898-2643 .- 1552-6887. ; 25:4, s. 589-616
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece. Method: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. Results: Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Discussion: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored.
Keyword
- folate
- B12
- cognitive impairment
- meta-analysis
- aged
Publication and Content Type
- ref (subject category)
- art (subject category)
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Michelakos, Theo ...
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Kousoulis, Anton ...
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Katsiardanis, Ko ...
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Dessypris, Nick
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Anastasiou, Anas ...
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Katsiardani, Kal ...
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Kanavidis, Prodr ...
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Stefanadis, Chri ...
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Papadopoulos, Fo ...
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Petridou, Eleni ...
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Journal of Aging ...
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Uppsala University