Search: onr:"swepub:oai:DiVA.org:uu-205113" > Genetic association...
Fältnamn | Indikatorer | Metadata |
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000 | 04865naa a2200541 4500 | |
001 | oai:DiVA.org:uu-205113 | |
003 | SwePub | |
008 | 130814s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:67b669cf-cf1b-4daf-8cfd-432940567794 | |
009 | oai:DiVA.org:liu-105186 | |
009 | oai:prod.swepub.kib.ki.se:128835237 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2051132 URI |
024 | 7 | a https://doi.org/10.1136/annrheumdis-2012-2025002 DOI |
024 | 7 | a https://lup.lub.lu.se/record/44823292 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1051862 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1288352372 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Reksten, Tove Ragnau Uppsala universitet,Reumatologi,University of Bergen, Norway / Uppsala University, Sweden4 aut |
245 | 1 0 | a Genetic associations to germinal centre formation in primary Sjögren's syndrome |
264 | c 2013-04-20 | |
264 | 1 | b BMJ,c 2014 |
338 | a print2 rdacarrier | |
520 | a BackgroundPrimary Sjögren's syndrome (pSS) is an autoimmune rheumatic disease mainly characterised by focal mononuclear cell infiltration in the salivary and lacrimal glands, and by the symptoms xerostomia and keratoconjunctivitis sicca. Germinal centre-like structures (GC) are found in the minor salivary glands of approximately 25% of patients. In this study, we aimed to assess genetic variations in pSS patients with GC-like formations (GC+) compared with patients without such formations (GC−).MethodsMinor salivary gland biopsies from Swedish and Norwegian pSS patients (n=320) were evaluated for GC-like formations, identifying 76 GC+ and 244 GC− patients. A panel of 1536 single-nucleotide polymorphisms (SNPs) in 107 genes was genotyped. Minor allele frequencies in GC+ and GC− patients were compared using Fisher's exact test, and associations were considered significant when p<4.7×10−4 and suggestive when p<0.01.ResultsIn this case-only analysis, we identified two SNPs in CCL11 (eotaxin) associated with GC-like structures (p<4.7×10−4, OR 0.45 and 0.41, respectively). A haplotype of the two minor alleles was associated with GC status with p=2.6×10−4, OR 0.40. Suggestive associations (p<0.01) were found in SNPs in the B cell activation and/or GC-formation related genes AICDA, BANK1 and BCL2. Furthermore, SNPs in IL17A, ICA1, PKN1 and SNPs in the NF-κB pathway genes CARD8, IKBKE and TANK were found suggestively associated with GC-like structures.ConclusionsOur findings suggest that genetic variations may explain why ectopic GC-like structures are present in some pSS patients, and support the hypothesis that GC+ and GC− patients represent distinct disease phenotypes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a Medicin | |
653 | a Medicine | |
700 | 1 | a Johnsen, Svein Joar Auglændu Stavanger University Hospital, Norway4 aut |
700 | 1 | a Jonsson, Malin Viktoriau University of Bergen, Norway4 aut |
700 | 1 | a Omdal, Roaldu Stavanger University Hospital, Norway4 aut |
700 | 1 | a Brun, Johan Gu University of Bergen, Norway4 aut |
700 | 1 | a Theander, Elkeu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital, Lund University, Malmö, Sweden4 aut0 (Swepub:lu)medf-eth |
700 | 1 | a Eriksson, Peru Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)perer22 |
700 | 1 | a Wahren-Herlenius, Marieu Karolinska Institutet4 aut |
700 | 1 | a Jonsson, Rolandu University of Bergen, Norway / Haukeland University Hospital, Bergen, Norway4 aut |
700 | 1 | a Nordmark, Gunnelu Uppsala universitet,Reumatologi,Uppsala University, Sweden4 aut0 (Swepub:uu)gunnnord |
710 | 2 | a Uppsala universitetb Reumatologi4 org |
773 | 0 | t Annals of the Rheumatic Diseasesd : BMJg 73:6, s. 1253-1258q 73:6<1253-1258x 0003-4967x 1468-2060 |
856 | 4 | u http://dx.doi.org/10.1136/annrheumdis-2012-202500y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205113 |
856 | 4 8 | u https://doi.org/10.1136/annrheumdis-2012-202500 |
856 | 4 8 | u https://lup.lub.lu.se/record/4482329 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105186 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128835237 |
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