Search: onr:"swepub:oai:DiVA.org:uu-210941" >
The Study of Active...
The Study of Active Monitoring in Sweden (SAMS) : A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer
-
- Bratt, Ola (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
-
- CARLSSON, STEFAN, 1987 (author)
- Karolinska Institutet
-
Holmberg, Erik (author)
-
show more...
-
- Holmberg, Lars (author)
- Uppsala universitet,Endokrinkirurgi
-
- Johansson, Eva (author)
- Uppsala universitet,Urologkirurgi
-
Josefsson, Andreas (author)
-
Nilsson, Annika (author)
-
Nyberg, Maria (author)
-
Robinsson, David (author)
-
- Sandberg, Jonas (author)
- Umeå universitet,Urologi och andrologi
-
Sandblom, Dag (author)
-
- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
-
show less...
-
(creator_code:org_t)
- 2013-07-24
- 2013
- English.
-
In: Scandinavian Journal of Urology. - : Medical Journals Sweden AB. - 2168-1805 .- 2168-1813. ; 47:5, s. 347-355
- Related links:
-
https://europepmc.or...
-
show more...
-
http://dx.doi.org/10...
-
http://www.ncbi.nlm....
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://research.cha...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Objective. Only a minority of patients with low-risk prostate cancer needs treatment, but the methods for optimal selection of patients for treatment are not established. This article describes the Study of Active Monitoring in Sweden (SAMS), which aims to improve those methods. Material and methods. SAMS is a prospective, multicentre study of active surveillance for low-risk prostate cancer. It consists of a randomized part comparing standard rebiopsy and follow-up with an extensive initial rebiopsy coupled with less intensive follow-up and no further scheduled biopsies (SAMS-FU), as well as an observational part (SAMS-ObsQoL). Quality of life is assessed with questionnaires and compared with patients receiving primary curative treatment. SAMS-FU is planned to randomize 500 patients and SAMS-ObsQoL to include at least 500 patients during 5 years. The primary endpoint is conversion to active treatment. The secondary endpoints include symptoms, distant metastases and mortality. All patients will be followed for 10-15 years. Results. Inclusion started in October 2011. In March 2013, 148 patients were included at 13 Swedish urological centres. Conclusions. It is hoped that the results of SAMS will contribute to fewer patients with indolent, low-risk prostate cancer receiving unnecessary treatment and more patients on active surveillance who need treatment receiving it when the disease is still curable. The less intensive investigational follow-up in the SAMS-FU trial would reduce the healthcare resources allocated to this large group of patients if it replaced the present standard schedule.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- biopsy
- patient selection
- prostatic neoplasm
- randomized clinical trial
- watchful waiting
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bratt, Ola
-
CARLSSON, STEFAN ...
-
Holmberg, Erik
-
Holmberg, Lars
-
Johansson, Eva
-
Josefsson, Andre ...
-
show more...
-
Nilsson, Annika
-
Nyberg, Maria
-
Robinsson, David
-
Sandberg, Jonas
-
Sandblom, Dag
-
Stattin, Pär
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Scandinavian Jou ...
- By the university
-
Uppsala University
-
Chalmers University of Technology
-
Lund University
-
Karolinska Institutet
-
Umeå University